116252-38-1Relevant articles and documents
NOVEL CEPHALOSPORINS
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Page/Page column 18-19, (2010/11/28)
The present invention relates to novel compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof.
Structure-activity relationships within a series of C(7)-substitutedoxyiminocephalosporins containing the C(3)-methylaminopyridiniumthiomethyl substituent synthesis and biological properties of BRL 57342 and some close analogues
Adams,Brain,Branch,Guest,Harrington,Mizen,Neale,Pearson,Simpson,Smulders,Zomaya
, p. 417 - 424 (2007/10/02)
(6R,7R)-7-[2-(2-Amino-4-thiazolyl)-2-[(Z)-[(S)-carboxy(3,4 -dihydroxyphenyl)methyl]oxy-imino]acetamido]-3-(1-methylaminopyridinium-4 -thiomethyl)ceph-3-em-4-carboxylate sodium salt (BRL 57342, If) combines excellent in vitro antibacterial potency against Gram-positive and Gram-negative bacteria, including P. aeruginosa and Acinetobacter spp., with excellent stability to extended spectrum β-lactamases. This potency is reflected in in vivo efficacy studies.