116296-94-7Relevant articles and documents
Assessing the stereoselectivity of: Serratia marcescens CECT 977 2,3-butanediol dehydrogenase
Médici, Rosario,Stammes, Hanna,Kwakernaak, Stender,Otten, Linda G.,Hanefeld, Ulf
, p. 1831 - 1837 (2017/07/15)
α-Hydroxy ketones and vicinal diols constitute well-known building blocks in organic synthesis. Here we describe one enzyme that enables the enantioselective synthesis of both building blocks starting from diketones. The enzyme 2,3-butanediol dehydrogenase (BudC) from S. marcescens CECT 977 belongs to the NADH-dependent metal-independent short-chain dehydrogenases/reductases family (SDR) and catalyses the selective asymmetric reductions of prochiral α-diketones to the corresponding α-hydroxy ketones and diols. BudC is highly active towards structurally diverse diketones in combination with nicotinamide cofactor regeneration systems. Aliphatic diketones, cyclic diketones and alkyl phenyl diketones are well accepted, whereas their derivatives possessing two bulky groups are not converted. In the reverse reaction vicinal diols are preferred over other substrates with hydroxy/keto groups in non-vicinal positions.
Asymmetric hydrogenation of 3,4-hexanedione over PtSn catalysts
Vetere, Virginia,Faraoni, Maria B.,Podesta, Julio C.,Casella, Monica L.
experimental part, p. 34 - 39 (2010/11/03)
In this work, some results of the liquid-phase racemic and enantioselective hydrogenation of 3,4-hexanedione are presented. The catalysts employed were platinum-based, supported on SiO2. Monometallic catalysts were modified with organotin precu