1163135-96-3

Basic information

• Product Name: BiMatoprost IMpurity III
• Synonyms: (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E)-3-oxo-5-phenyl-1-penten-1-yl]cyclopentyl]-N-ethyl-5-heptenaMide;15-Keto BiMatoprost;BiMatoprost IMpurity III;(5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E)-3-oxo-5-phenyl-1-penten-1-yl]cyclopentyl]-N-(ethyl-d5)-5-heptenaMide;15-Keto BiMatoprost-d5;15-keton-Bimatoprost;15-keto-17-phenyl trinor Prostaglandin F2.alpha. ethyl amide;5-Keto BiMatoprost
• CAS NO: 1163135-96-3
• Molecular Formula: C₂₅H₃₅NO₄
• Molecular Weight: 418.58050889
• Mol File: 1163135-96-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 626.7±55.0 °C(Predicted)
• Appearance: /
• Density: 1.142±0.06 g/cm3(Predicted)
• Storage Temp.: Amber Vial, -20°C Freezer, Under inert atmosphere
• Solubility: Dichloromethane (Slightly), Methanol (Slightly)
• PKA: 14.42±0.70(Predicted)
• Stability: Light Sensitive
• CAS DataBase Reference: BiMatoprost IMpurity III(CAS DataBase Reference)
• NIST Chemistry Reference: BiMatoprost IMpurity III(1163135-96-3)
• EPA Substance Registry System: BiMatoprost IMpurity III(1163135-96-3)

Safety Data

• Hazardous Substances Data: 1163135-96-3(Hazardous Substances Data)

Usage

Description

Bimatoprost Impurity III, also known as 15-Keto Bimatoprost (K175100), is an impurity found in Bimatoprost (B386800), a prostamide analog used in the treatment of glaucoma and ocular hypertension. It is a chemical compound derived from the primary substance Bimatoprost, which is known for its ability to lower intraocular pressure by increasing the outflow of aqueous humor.

Uses

Used in Pharmaceutical Industry:
Bimatoprost Impurity III is used as a reference standard for the identification, quality control, and assurance of the purity and potency of Bimatoprost in the pharmaceutical industry. It helps in the development, manufacturing, and regulatory compliance of Bimatoprost-containing products, ensuring their safety and efficacy for patients.
Used in Research and Development:
Bimatoprost Impurity III is used as a research tool in the study of the pharmacological properties, mechanisms of action, and potential side effects of Bimatoprost. It aids in understanding the differences in the biological activities between the impurity and the parent compound, which can be crucial for the optimization of drug formulations and the development of new therapeutic agents.
Used in Quality Control and Regulatory Compliance:
Bimatoprost Impurity III is used as a critical component in the quality control processes and regulatory compliance of Bimatoprost-containing products. It helps in the establishment of acceptable impurity levels, ensuring that the final drug product meets the required safety and efficacy standards set by regulatory authorities.
Used in Drug Safety Assessment:
Bimatoprost Impurity III is used in the assessment of drug safety, particularly in the evaluation of potential toxicities and adverse effects associated with the use of Bimatoprost. Understanding the properties and effects of this impurity can contribute to the overall safety profile of Bimatoprost and inform decisions regarding its clinical use and dosage recommendations.

Upstream product

• 155206-00-1 bimatoprost 

Downstream Products

• 1163135-92-9 (5Z)-N-ethyl-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-5-phenyl-1-pentenyl]-cyclopentyl]hept-5-enamide 

Relevant articles and documents

Bimatoprost crystalline form I

The invention provides a novel polymorphic form I of crystalline bimatoprost, method for preparation thereof and new crystalline intermediates in the preparation. This form I of crystalline bimatoprost is used in purification of crude bimatoprost and in storage of bimatoprost as active pharmaceutical intermediate. Use of the physical form of bimatoprost in the manufacture of a medicament is also disclosed.