116344-18-4 Usage
Description
5-Isopropyl-1-phenyl-1H-pyrazole-4-carboxylic acid is a chemical compound derived from the reaction of 2-dimethylaminomethylene-1,3-diones with dinucleophiles. It is characterized by its unique molecular structure, which consists of a pyrazole ring fused with a phenyl group and an isopropyl substituent, along with a carboxylic acid functional group. 5-Isopropyl-1-phenyl-1H-pyrazole-4-carboxylic acid holds potential for various applications in different industries due to its chemical properties and reactivity.
Uses
Used in Pharmaceutical Industry:
5-Isopropyl-1-phenyl-1H-pyrazole-4-carboxylic acid is used as a building block for the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications, such as anti-inflammatory, analgesic, and anti-cancer agents. The carboxylic acid group in the molecule enables further chemical modifications and functionalization, making it a versatile starting material for drug discovery and development.
Used in Chemical Synthesis:
In the field of organic chemistry, 5-Isopropyl-1-phenyl-1H-pyrazole-4-carboxylic acid serves as an important intermediate for the synthesis of a wide range of chemical products. Its reactivity and structural features make it suitable for use in the preparation of various organic compounds, including dyes, pigments, and other specialty chemicals. The isopropyl and phenyl groups in the molecule can be further modified to produce a diverse array of products with different properties and applications.
Used in Material Science:
5-Isopropyl-1-phenyl-1H-pyrazole-4-carboxylic acid can be utilized in the development of novel materials with specific properties. For instance, its incorporation into polymer structures can lead to the creation of new polymers with enhanced mechanical, thermal, or electrical properties. Additionally, the compound's ability to form complexes with metal ions can be exploited in the design of advanced materials for applications such as sensors, catalysts, or energy storage devices.
Used in Agrochemical Industry:
The unique chemical structure of 5-Isopropyl-1-phenyl-1H-pyrazole-4-carboxylic acid also makes it a potential candidate for use in the agrochemical industry. It can be employed as a starting material for the synthesis of new pesticides, herbicides, or plant growth regulators. The compound's potential to modulate various biological processes may also be harnessed for the development of innovative agrochemical products with improved efficacy and selectivity.
Used in Research and Development:
5-Isopropyl-1-phenyl-1H-pyrazole-4-carboxylic acid is a valuable compound for research and development purposes. Its unique structure and reactivity make it an attractive target for studying various chemical reactions and mechanisms. Additionally, its potential applications in different industries provide a strong impetus for further research to explore its full range of possibilities and optimize its synthesis and functionalization for specific uses.
Check Digit Verification of cas no
The CAS Registry Mumber 116344-18-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,6,3,4 and 4 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 116344-18:
(8*1)+(7*1)+(6*6)+(5*3)+(4*4)+(3*4)+(2*1)+(1*8)=104
104 % 10 = 4
So 116344-18-4 is a valid CAS Registry Number.
InChI:InChI=1/C13H14N2O2/c1-9(2)12-11(13(16)17)8-14-15(12)10-6-4-3-5-7-10/h3-9H,1-2H3,(H,16,17)
116344-18-4Relevant articles and documents
Pyrazole-4-Carboxamide (YW2065): A Therapeutic Candidate for Colorectal Cancer via Dual Activities of Wnt/β-Catenin Signaling Inhibition and AMP-Activated Protein Kinase (AMPK) Activation
Yang, Wei,Li, Yingjun,Ai, Yong,Obianom, Obinna N.,Guo, Dong,Yang, Hong,Sakamuru, Srilatha,Xia, Menghang,Shu, Yan,Xue, Fengtian
, p. 11151 - 11164 (2019/12/27)
Dysregulation of the Wnt/β-catenin signaling pathway has been widely recognized as a pathogenic mechanism for colorectal cancer (CRC). Although numerous Wnt inhibitors have been developed, they commonly suffer from toxicity and unintended effects. Moreover, concerns have been raised in targeting this pathway because of its critical roles in maintaining stem cells and regenerating tissues and organs. On the basis of the anthelmintic drug pyrvinium and previous lead FX1128, we have developed a compound YW2065 (1c) which demonstrated excellent anti-CRC effects in vitro and in vivo. YW2065 achieves its inhibitory activity for Wnt signaling by stabilizing Axin-1, a scaffolding protein that regulates proteasome degradation of β-catenin. Simultaneously, YW2065 also led to the activation of the tumor suppressor AMPK, providing an additional anticancer mechanism. In addition, YW2065 showed favorable pharmacokinetic properties without obvious toxicity. The anti-CRC effect of YW2065 was highlighted by its promising efficacy in a mice xenograft model.
