116433-58-0

Basic information

• Product Name: N-benzyl-2-(phenylamino)acetamide
• Synonyms: N-benzyl-2-(phenylamino)acetamide
• CAS NO: 116433-58-0
• Molecular Formula: C₁₅H₁₆N₂O
• Molecular Weight: 240.30034
• Mol File: 116433-58-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 108-109 °C
• Boiling Point: 502.4±43.0 °C(Predicted)
• Appearance: /
• Density: 1.152±0.06 g/cm3(Predicted)
• PKA: 14.91±0.46(Predicted)
• CAS DataBase Reference: N-benzyl-2-(phenylamino)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-2-(phenylamino)acetamide(116433-58-0)
• EPA Substance Registry System: N-benzyl-2-(phenylamino)acetamide(116433-58-0)

Safety Data

• Hazardous Substances Data: 116433-58-0(Hazardous Substances Data)

Upstream product

• 116433-53-5 2-azido-N-(phenylmethyl)acetamide 
• 71-43-2 benzene 
• 100-46-9 benzylamine 
• 122-98-5 2-Anilinoethanol 
• 2564-06-9 N-benzyl-2-chloroacetamide 
• 62-53-3 aniline 
• 2216-92-4 N-phenylglycine ethyl ester 
• 103-01-5 N-Phenylglycine 

Relevant articles and documents

Regioselective synthesis of: Ortho -iodobiphenylboronic acid derivatives: A superior catalyst for carboxylic acid activation

An efficient and versatile synthesis of ortho-iodobiphenylboronic acids via the highly regioselective metal-iodine exchange (MIE) of 2,3-diiodobiphenyls is reported. The site-selectivity is very much controlled by the size of the biphenyl fragment, providing only the terminal arylboronic acid derivatives in excellent site-selectivity. The nature of the substituents (R1 and R2) on the biphenyls is found to have an influence on the reactivity but not on the regioselectivity. The best reactivity and the highest isolated yields were furnished with products bearing electron-donating groups. The synthesized derivatives were also tested for in vitro antimicrobial activity against four strains of bacteria and one fungal strain. This revealed that (2-iodo-4′-isopropyl-[1,1′-biphenyl]-3-yl)boronic acid 6A and (3-(benzo[d][1,3]dioxol-5-yl)-2-iodo-5-methoxyphenyl)boronic acid 22A possess the most potent antibacterial and antifungal activity with MICs of 0.10 and 0.3 mg mL-1 for B. cereus and C. albicans respectively. The catalytic activity was also examined towards an amidation reaction at ambient temperature and this revealed a new optimal catalyst, (2-iodo-4′,5-dimethoxy-[1,1′-biphenyl]-3-yl)boronic acid 19A providing a remarkable increase in the amide yields, including α-aminoacids. This work discloses a protocol for the first synthesis of hitherto unknown ortho-iodobiphenylboronic acid derivatives that is scalable, and general in scope, where no chromatographic purification is necessary and the products are indeed potential organocatalysts.

Amino acid derivative anticonvulsant

The present invention relates to compounds of the formula STR1

Reaction of Azides in Presence of Aluminium Chloride

Amidoalkylazides (2) on treatment with aluminium chloride in benzene yield 2-anilino-N-(aryl)acetamides (3) in good yields.