116705-41-0 Usage
Description
(E)-6-(2-(dimethylamino)vinyl)-5-nitropyrimidine-2,4(1H,3H)-dione is a chemical compound characterized by its molecular formula C9H8N4O4. It is a nitro-substituted pyrimidine derivative featuring a vinyl group with a dimethylamino substituent. (E)-6-(2-(dimethylamino)vinyl)-5-nitropyrimidine-2,4(1H,3H)-dione is known for its unique structure and functional groups, which make it a valuable building block in the synthesis of various pharmaceuticals and organic compounds. The presence of nitro and vinyl groups allows for further chemical modifications and derivatizations, enabling the compound to be tailored for specific applications in medicinal and synthetic chemistry.
Uses
Used in Pharmaceutical Synthesis:
(E)-6-(2-(dimethylamino)vinyl)-5-nitropyrimidine-2,4(1H,3H)-dione is used as an intermediate or starting material for the synthesis of various pharmaceuticals and organic compounds. Its unique structure and functional groups make it a valuable building block in the production of biologically active molecules and materials.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (E)-6-(2-(dimethylamino)vinyl)-5-nitropyrimidine-2,4(1H,3H)-dione is used as a key component in the development of new drugs and therapeutic agents. Its versatile structure allows for the creation of molecules with specific biological activities, targeting various diseases and medical conditions.
Used in Synthetic Chemistry:
(E)-6-(2-(dimethylamino)vinyl)-5-nitropyrimidine-2,4(1H,3H)-dione is also utilized in synthetic chemistry as a precursor for the synthesis of a wide range of organic compounds. (E)-6-(2-(dimethylamino)vinyl)-5-nitropyrimidine-2,4(1H,3H)-dione's functional groups provide opportunities for further chemical modifications, making it a versatile building block for the creation of novel materials and compounds with specific properties and applications.
Check Digit Verification of cas no
The CAS Registry Mumber 116705-41-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,6,7,0 and 5 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 116705-41:
(8*1)+(7*1)+(6*6)+(5*7)+(4*0)+(3*5)+(2*4)+(1*1)=110
110 % 10 = 0
So 116705-41-0 is a valid CAS Registry Number.
116705-41-0Relevant articles and documents
Discovery of potent dipeptidyl peptidase IV inhibitors through pharmacophore hybridization and hit-to-lead optimization
Zeng, Shaogao,Xie, Hui,Zeng, Li-Li,Lu, Xin,Zhao, Xin,Zhang, Gui-Cheng,Tu, Zheng-Chao,Xu, Hong-Jiang,Yang, Ling,Zhang, Xi-Quan,Hu, Wenhui
, p. 1749 - 1755 (2013)
A novel dipeptidyl peptidase IV inhibitor hit (5, IC50 = 0.86 μM) was structurally derived from our recently disclosed preclinical candidate 4 by replacing the cyanobenzyl with a butynyl based on pharmacophore hybridization. A hit-to-lead optimization effort was then initiated to improve its potency. Most N-substituted analogs exhibited good in vitro activity, and compound 18o (IC50 = 1.55 nM) was identified to be a potent dipeptidyl peptidase IV inhibitor with a significantly improved pharmacokinetic properties (bioavailablity: 41% vs 82.9%; T1/2: 2 h vs 4.9 h).
Pyrrolopyrimidine ketone compound and preparation method and application thereof
-
, (2017/07/21)
The invention relates to a pyrrolopyrimidine ketone compound and a preparation method and application thereof, and belongs to the technical field of medicine. The pyrrolopyrimidine ketone compound having a structural feature of formula I, or a pharmaceutically acceptable salt thereof has a very good inhibition effect on DPP-IV, and almost no effect on activity of DPP-VIII and DPP-IX, can effectively control the blood glucose concentration of diabetic rats, and is safe and low in toxicity through the verification of pharmacological and toxicological tests. After being prepared into a medicine, the compound provided by the invention not only has an obvious efficacy but also has very small side effects, thus greatly improving the administration convenience and patient use compliance, therefore, the compound has obvious advantages compared with the same kind of medicine. The formula is shown in the specification.
SYNTHESIS AND BIOLOGICAL ACTIVITY OF AMINOPYRROLOPYRIMIDINES
Modnikova, G. A.,Titkova, R. M.,Glushkov, R. G.,Sokolova, A. S.,Silin, V. A.,Chernov, V. A.
, p. 135 - 141 (2007/10/02)
-