116763-08-7

Basic information

• Product Name: methyl (S)-3-phenyl-2-(1H-pyrrol-1-yl)propanoate
• Synonyms: methyl (S)-3-phenyl-2-(1H-pyrrol-1-yl)propanoate
• CAS NO: 116763-08-7
• Molecular Weight: 229.279
• Mol File: 116763-08-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: methyl (S)-3-phenyl-2-(1H-pyrrol-1-yl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (S)-3-phenyl-2-(1H-pyrrol-1-yl)propanoate(116763-08-7)
• EPA Substance Registry System: methyl (S)-3-phenyl-2-(1H-pyrrol-1-yl)propanoate(116763-08-7)

Safety Data

• Hazardous Substances Data: 116763-08-7(Hazardous Substances Data)

Upstream product

• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 79561-72-1 N,N-bis-allyl-L-phenylalanine methyl ester 

Downstream Products

• 123366-90-5 (S)-3-phenyl-2-(1H-pyrrol-1-yl)propan-1-ol 
• 123366-98-3 3-phenyl-2-(pyrrol-1-yl)propanal 
• 918164-92-8 (S)-methyl 2-(2-formyl-1H-pyrrol-1-yl)-3-phenylpropanoate 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 51987-73-6 (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester 
• 123366-98-3 3-Phenyl-2-pyrrol-1-yl-propionaldehyde 

Relevant articles and documents

Microwave-assisted ring-closing metathesis of diallylamines: a rapid synthesis of pyrrole and pyrroline derivatives

The ring-closing metathesis (RCM) reactions of diallylamines occurred under controlled microwave irradiation. In addition to the high reaction rate, the key features of the reaction are that it can be carried out without deactivation of the substrates and

Nonenzymatic, enantioconvergent dynamic kinetic resolution (DKR) of racemic 2-(1H-pyrrol-1-yl)alkanoic acids as α-amino acid equivalents

We report an effective dynamic kinetic resolution (DKR) system of racemic 2-(1H-pyrrol-1-yl)alkanoic acids, which consists of a rapid racemization step via an activating substrate and an enantio-discriminating step via catalytic esterification. The combination of pivalic anhydride as an activating agent, bis(α-naphthyl)methanol as an achiral alcohol, (R)-BTM as a chiral acyl-transfer catalyst, and Hunig's base converted racemic 2-(1H-pyrrol-1-yl)alkanoic acids to the corresponding chiral carboxylates, which can be transformed into chiral α-amino acid derivatives with maintained high enantiopurity.

Peptide Synthesis Using the Pyrrole Ring as an Amino Protecting Group

The utility of a pyrrole ring as an amino protecting group for amino acids in peptide synthesis has been studied.The N-termini of various amino acids (1) were protected with a pyrrole ring by treatment with 2,5-dimethoxytetrahydrofuran (10) to give 2-substituted 2-(1-pyrrolyl)acetic acids (11).The peptide bond between (11) and amino acid methyl ester (2) was formed using N,N'-dicyclohexylcarbodiimide, and the pyrrole ring was cleaved by ozonolysis and hydrolysis without the cleavage of a peptide bond to give the corresponding dipeptide compounds (26) in good yields.