116799-23-6Relevant articles and documents
An efficient synthesis of cyanoarenes and cyanoheteroarenes via lithiation followed by electrophilic cyanation
Sato, Nobuhiro,Yue, Qi
, p. 5831 - 5836 (2007/10/03)
A one-pot procedure for the conversion of mono-substituted arenes and heteroarenes into the ortho-cyano derivatives was achieved through directed lithiation followed by electrophilic cyanation with phenyl cyanate. This reaction method proved to be applicable to halogen-lithium exchanged intermediates, so especially useful for the synthesis of benzonitriles. The scope of the reaction sequence was explored using a number of substrates.