1168015-95-9Relevant articles and documents
Highly efficient prolinamide-based organocatalysts for the direct asymmetric aldol reaction in brine
Jia, Ya-Ning,Wu, Feng-Chun,Ma, Xiao,Zhu, Gong-Jian,Da, Chao-Shan
, p. 3059 - 3062 (2009)
Four prolinamide-based organocatalysts were readily synthesized and applied to the direct asymmetric aldol reactions of ketones and aromatic aldehydes in brine. When 2,4-dinitrophenol (DNP) was used as an acidic additive, 1 mol % low loading of 2b afforded aldol products with excellent diastereoselectivity of up to 98/2 dr and high enantioselectivity of up to 97% ee.