116856-18-9

Basic information

• Product Name: 5-Formamide-1-(2-formyloxyethl)pyrazole
• Synonyms: 5-FORMAMIDO-1-(2-FORMYLOXYETHYL)PYRAZOLE;5-Formamide-1-(2-formyloxyethl)pyrazole;N-[1-[2-(Formyloxy)ethyl]-1H-pyrazol-5-yl]formamide;CYCLOPENTANEMETHYLAMINE HCL;5-formamido-1-(2-formyloxyethyl)-1H-pyrazole;2-(5-forMaMido-1H-pyrazol-1-yl)ethyl forMate;ForMaMide,N-[1-[2-(forMyloxy)ethyl]-1H-pyrazol-5-yl]-;2-(5-Formamido-1H-pyrazol-1-yl)
• CAS NO: 116856-18-9
• Molecular Formula: C₇H₉N₃O₃
• Molecular Weight: 183.16
• EINECS: 1308068-626-2
• Mol File: 116856-18-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 84-86 °C
• Boiling Point: 414.8 °C at 760 mmHg
• Flash Point: 204.7 °C
• Appearance: /Solid
• Density: 1.32
• Vapor Pressure: 4.32E-07mmHg at 25°C
• Refractive Index: 1.572
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 14.29±0.70(Predicted)
• CAS DataBase Reference: 5-Formamide-1-(2-formyloxyethl)pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Formamide-1-(2-formyloxyethl)pyrazole(116856-18-9)
• EPA Substance Registry System: 5-Formamide-1-(2-formyloxyethl)pyrazole(116856-18-9)

Safety Data

• Hazardous Substances Data: 116856-18-9(Hazardous Substances Data)

Usage

General Description

5-Formamide-1-(2-formyloxyethyl)pyrazole is a chemical compound with the molecular formula C8H10N2O3. It is a pyrazole derivative that contains a formamide group and a formyloxyethyl group. 5-Formamide-1-(2-formyloxyethl)pyrazole is commonly used in organic synthesis and pharmaceutical research due to its potential bioactivity and versatile reactivity. It has been studied for its potential applications in the development of new drugs and as a building block in the synthesis of complex organic molecules. The unique structure of 5-Formamide-1-(2-formyloxyethyl)pyrazole allows it to participate in a variety of chemical reactions, making it a valuable tool for chemical research and drug discovery.

InChI:InChI=1/C7H9N3O3/c11-5-8-7-1-2-9-10(7)3-4-13-6-12/h1-2,5-6H,3-4H2,(H,8,11)

Upstream product

• 73616-27-0 5-amino-1-(2-hydroxyethyl)-1H-pyrazole 
• 64-18-6 formic acid 

Relevant articles and documents

Studies on 3'-quaternary ammonium cephalosporins-IV. Synthesis and antibacterial activity of 3'-(2-alkyl-3-aminopyrazolium)cephalosporins related to FK037

The synthesis and in vitro antibacterial activity of 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido] cephalosporins bearing various 2-alkyl-3-aminopyrazolium groups at the 3-position are described. Antibacterial activity against MRSA was affected by the nature of the substituent at the 2-position on the 3'-aminopyrazolium groups. Among the cephalosporins prepared in this study, 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-[3-amino-2-(2 -hydroxyethyl)-pyrazolio]methyl-3-cephem-4-carboxylate sulfate (23e, FK037) showed extremely potent broad-spectrum activity against both Gram-positive bacteria including MRSA, and Gram-negative bacteria including Pseudomonas aeruginosa. In particular, the in vivo activity against MRSA of FK037 was the highest of all the β-lactam antibiotics tested.

Cephem compounds and processes for preparation thereof

7 β-[2-5 amino-1, 2, 4 thiadiazol-3yl) 2(carboxy lower alkyleneoxyimino) acetamido]-3-(3-amino-2-alkyl-1-pyrazolio) methyl 3 cephem 4 carboxylates are prepared. They are antibiotics.