116922-61-3 Usage
General Description
4-Fluoro-3-(trimethylsilyl)pyridine is a chemical compound with the molecular formula C8H11FNSi. It is a pyridine derivative that contains a fluorine atom and a trimethylsilyl group. 4-FLUORO-3-(TRIMETHYLSILYL)PYRIDINE is commonly used as a reagent in organic synthesis, particularly in the formation of carbon-carbon and carbon-nitrogen bonds. It is also utilized as a protecting group in the synthesis of complex organic molecules. Additionally, 4-fluoro-3-(trimethylsilyl)pyridine has potential applications in pharmaceutical and agrochemical industries due to its ability to facilitate the synthesis of biologically active compounds. Due to its reactive nature, this compound should be handled and stored with care to prevent accidents or exposure to harmful effects.
Check Digit Verification of cas no
The CAS Registry Mumber 116922-61-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,6,9,2 and 2 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 116922-61:
(8*1)+(7*1)+(6*6)+(5*9)+(4*2)+(3*2)+(2*6)+(1*1)=123
123 % 10 = 3
So 116922-61-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H12FNSi/c1-11(2,3)8-6-10-5-4-7(8)9/h4-6H,1-3H3
116922-61-3Relevant articles and documents
Directed Lithiation of 4-Halopyridines: Chemoselectivity, Regioselectivity and Application to Synthesis
Marsais, F.,Trecourt, F.,Breant, P.,Queguiner, G.
, p. 81 - 87 (2007/10/02)
4-Chloro and 4-fluoropyridines were ortho-lithiated by n-butyllithium-TMEDA chelate or lithium diisopropylamide at low temperature.The resulting 3-lithio 4-halopyridines were reacted with electrophiles which led to various 3,4-disubstituted pyridines.The versatility of this functionalization is enhanced by the 4-halogen reactivity towards nucleophiles such as water, methylate and amines.Some of the 3,4-disubstituted synthons were annelated to naphthyridine, xanthone and coumarin or condensed to Hantzsch-ester or to "chlotrimazol" analogues.Lithiation of 4-fluoropyridine led in one step to 3,4-pyridyne, which was trapped by cycloaddition with furans.
