1169704-19-1

Basic information

• Product Name: (S)-ethyl 3-((R)-1,1-dimethylethylsulfinamido)-3-phenylpropanoate
• Synonyms: (S)-ethyl 3-((R)-1,1-dimethylethylsulfinamido)-3-phenylpropanoate
• CAS NO: 1169704-19-1
• Molecular Weight: 297.419
• Mol File: 1169704-19-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-ethyl 3-((R)-1,1-dimethylethylsulfinamido)-3-phenylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-ethyl 3-((R)-1,1-dimethylethylsulfinamido)-3-phenylpropanoate(1169704-19-1)
• EPA Substance Registry System: (S)-ethyl 3-((R)-1,1-dimethylethylsulfinamido)-3-phenylpropanoate(1169704-19-1)

Safety Data

• Hazardous Substances Data: 1169704-19-1(Hazardous Substances Data)

Upstream product

• 196929-85-8 (R)-N-benzylidene-2-methylpropane-2-sulfinamide 
• 4071-88-9 trimethylsilanyl-acetic acid ethyl ester 
• 105-36-2 ethyl bromoacetate 
• 186249-76-3 (R,E)-2-methyl-N-(phenylmethylene)-2-propanesulfinamide 

Downstream Products

• 3082-69-7 ethyl (3S)-3-amino-3-phenylpropionate 

Relevant articles and documents

Scalable scny BRAnthesis of β-amino esters via reformatskcny BRA reaction with N-tert-butanesulfincny BRAl imines

The Reformatskcny BRA reagents derived from ethcny BRAl bromoacetate and tert-butcny BRAl bromoacetate add cleanlcny BRA, in high cny BRAield, and with good diastereoselectivitcny BRA to N-tert-butanesulfincny BRAl aldimines and ketimines. Importantlcny BRA, this reaction scales well (>50 mmol), and affords products upwards of 70% cny BRAield over three steps, starting from commerciallcny BRA available N-tert-butanesulfinamide, aldehcny BRAdes, and ketones.

SmI2-promoted imino-Reformatsky reaction for facile synthesis of enantioenriched β-amino acid esters

A facile and efficient method for the stereoselective synthesis of β-amino acid esters via SmI2-promoted imino-Reformatsky reaction is described. Asymmetric addition of tert-butyl bromoacetate to N-tert-butanesulfinyl aldimines afforded β-amino