116993-95-4Relevant articles and documents
Evaluation of transition-state mimics in a superior BACE1 cleavage sequence as peptide-mimetic BACE1 inhibitors
Hattori, Yasunao,Kobayashi, Kazuya,Deguchi, Ayaka,Nohara, Yukie,Akiyama, Tomomi,Teruya, Kenta,Sanjoh, Akira,Nakagawa, Atsushi,Yamashita, Eiki,Akaji, Kenichi
, p. 5626 - 5640 (2015/11/11)
A superior substrate sequence for BACE1 containing transition-state mimics at the scissile site was evaluated as a protease inhibitor. Hydroxymethylcarbonyl (HMC) and hydroxyethylamine (HEA) isosteres were selected as the transition state mimics, and inco
5-substituted amino-4-hydroxy-pentanoic acid derivatives and their use
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, (2008/06/13)
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