1169974-48-4

Basic information

• Product Name: C₁₆H₁₈N₂O₃
• Synonyms: C₁₆H₁₈N₂O₃
• CAS NO: 1169974-48-4
• Molecular Weight: 286.331
• Mol File: 1169974-48-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₈N₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₈N₂O₃(1169974-48-4)
• EPA Substance Registry System: C₁₆H₁₈N₂O₃(1169974-48-4)

Safety Data

• Hazardous Substances Data: 1169974-48-4(Hazardous Substances Data)

Upstream product

• 1243348-06-2 (4aR,7aS)-1-methylcarbonylhexahydrofuro [3,4-b] pyridine-5,7-dione 

Downstream Products

• 151213-39-7 (S,S)-8-benzyl-2,8-diazabicyclo[4.3.0]nonane-D-tartrate 
• 313639-98-4 cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane hydrochloride 

Relevant articles and documents

SYNTHESIS OF (4aS,7aS)-OCTAHYDRO-1H-PYRROLO[3,4-b]PYRIDINE

The present invention relates to the stereoselective synthesis of (4aS,7aS)-octahydro-1H-pyrrolo [3, 4-b]pyridine, as well as the conversion thereof, to give Moxifloxacin. Particularly, the present invention relates to a method for the synthesis of (4aS,7aS)-octahydro-1H-pyrrolo[3, 4-b]pyridine of formula (I) comprising : (a) the optical resolution by enzymatic hydrolysis of the intermediate dialkyl-1-alkylcarbonylpiperidine-2,3-dicarboxylate racemate of formula (II) to give, following isolation, the intermediate dialkyl-(2S,3R)-1-alkylcarbonyl-piperidine-2,3-dicarboxylate of formula (III) in which AIk is a straight or branched C1-C5 alkyl group; (b) the conversion of the intermediate (III) to (4aR,7aS)-1-alkylcarbonylhexahydrofuro[3, 4-b]pyridine-5,7-dione of formula (IV) in which AIk has the meanings set forth above; (c) the conversion of the intermediate (IV) to (4aS,7as)-octahydro-1H-pyrrolo[3, 4-b]pyridine of formula (I) with an optical purity above 99%.