117-02-2Relevant articles and documents
-
Mitter
, (1928)
-
Design, Synthesis, Molecular Docking, and Biological Evaluation of New Emodin Anthraquinone Derivatives as Potential Antitumor Substances
Li, Yuying,Guo, Fang,Chen, Tinggui,Zhang, Liwei,Wang, Zhuanhua,Su, Qiang,Feng, Liheng
, (2020)
The emodin anthraquinone derivatives are generally used in traditional Chinese medicine due to their various pharmacological activities. In the present study, a series of emodin anthraquinone derivatives have been designed and synthesized, among which 1,3-dihydroxy-6,8-dimethoxyanthracene-9,10-dione is a natural compound that has been synthesized for the very first time, and 1,3-dimethoxy-5,8-dimethylanthracene-9,10-dione is a compound that has never been reported earlier. Interestingly, while total seven of these compounds showed neuraminidase inhibitory activity in influenza virus with inhibition rate more than 50 %, specific four compounds exhibited significant inhibition of tumor cell proliferation. The further results demonstrate that 1,3-dimethoxy-5,8-dimethylanthracene-9,10-dione showed the best anticancer activity among all the synthesized compounds by inducing highest apoptosis rate to HCT116 cancer cells and arresting their G0/G1 cell cycle phase, through elevation of intracellular level of reactive oxygen species (ROS). Moreover, the binding of 1,3-dimethoxy-5,8-dimethylanthracene-9,10-dione with BSA protein has thoroughly been investigated. Altogether, this study suggests the neuraminidase inhibitory activity and antitumor potential of the new emodin anthraquinone derivatives.
Method for continuously producing 2, 6-dihydroxytoluene
-
Paragraph 0027, (2021/08/11)
The invention discloses a method for continuously producing 2, 6-dihydroxytoluene. According to the method, 3-chloro-2-methylaniline is taken as a raw material, diazotization is carried out through a micro-channel reactor to synthesize an intermediate 3-chloro-2-methylphenol, and then 2, 6-dihydroxytoluene is synthesized. According to the method, the micro-channel reactor is used for diazotization of 3-chloro-2-methylaniline so that severe heat release and unstable properties of the product in the reaction process can be effectively avoided, the retention time is short, the next reaction is directly carried out after the reaction is finished, the continuous reaction can be experimented, the yield of the diazotization step can be increased to 85-95% from the traditional 75-85%, the total yield of the 2, 6-dihydroxytoluene is increased to 80-90%, and the product purity can be up to more than or equal to 99.0%.