1171064-51-9Relevant articles and documents
Construction of All-Carbon Chiral Quaternary Centers through CuI-Catalyzed Enantioselective Reductive Hydroxymethylation of 1,1-Disubstituted Allenes with CO2
Qiu, Jia,Gao, Shen,Li, Chaopeng,Zhang, Lei,Wang, Zheng,Wang, Xiaoming,Ding, Kuiling
, p. 13874 - 13878 (2019)
A catalytic enantioselective construction of all-carbon chiral quaternary centers through reductive hydroxymethylation of 1,1-disubstituted allenes with CO2 has been developed. In the presence of a copper/Mandyphos catalyst, CO2 is t
Synthesis of cyclopropenes via 1,2-elimination of bromocyclopropanes catalyzed by crown ether
Sherrill, William M.,Kim, Ryan,Rubin, Michael
scheme or table, p. 1477 - 1484 (2009/12/31)
A new synthetic protocol for the preparation of 3,3-disubstituted cyclopropenes from the corresponding bromocyclopropanes via a base-assisted 1,2-elimination has been developed. Employment of catalytic amounts of 18-crown-6 in ethereal solvents allowed for improved yields, as compared to the classical procedure employing dimethyl sulfoxide, making this protocol applicable to the synthesis of hydrophilic cyclopropenes. The application of this new method for the efficient synthesis of cyclopropene-3-carboxamides, an important class of functionalized 3,3-disubstituted cyclopropenes, is demonstrated. Scope and limitation studies are discussed. Georg Thieme Verlag Stuttgart.
