1173289-25-2

Basic information

• Product Name: 4-(2-(2-methoxyethylamino)ethyl)phenol
• Synonyms: 4-(2-(2-methoxyethylamino)ethyl)phenol
• CAS NO: 1173289-25-2
• Molecular Weight: 195.261
• Mol File: 1173289-25-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2-(2-methoxyethylamino)ethyl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-(2-methoxyethylamino)ethyl)phenol(1173289-25-2)
• EPA Substance Registry System: 4-(2-(2-methoxyethylamino)ethyl)phenol(1173289-25-2)

Safety Data

• Hazardous Substances Data: 1173289-25-2(Hazardous Substances Data)

Upstream product

• 14140-15-9 4-(2-bromoethyl)phenol 
• 109-85-3 2-methoxyethylamine 

Downstream Products

• 1173289-67-2 (S)-2-(3-benzoylphenyl)-N-(4-hydroxyphenethyl)-N-(2-methoxyethyl)propanamide 

Relevant articles and documents

Structure-activity relationships and cancer-cell selective toxicity of novel inhibitors of glioma-associated oncogene homologue 1 (Gli1) mediated transcription

We report novel inhibitors of Gli1-mediated transcription as potential anticancer agents. Focused chemical libraries were designed and assessed for inhibition of functional cell-based Gli1-mediated transcription and selective toxicity toward cancer cells. The SAR was revealed, and the selectivity of the lead compounds' inhibition of Gli1-mediated transcription over that of Gli2 was determined. Compound 63 (NMDA298-1), which inhibited Gli1-mediated transcription in C3H10T1/2 cells with an IC50 of 6.9 μM, showed 3-fold selectivity for inhibiting transcription mediated by Gli1 over that by Gli2. Cell-viability assays were performed to evaluate the chemical library in a normal cell line and a panel of cancer cell lines with or without up-regulated expression of the Gli1 gene. These compounds decreased the viability of several cancer cell lines but were less active in the noncancerous BJ-hTERT cells. 2009 American Chemical Society.