117391-48-7

Basic information

• Product Name: 2-AMINO-3-METHYLQUINOLINE HYDROCHLORIDE
• Synonyms: RARECHEM AK HC T304;VITAS-BB TBB000176;BIO-FARMA BF000136;DL-3-AMINO-3-(2-BROMO-PHENYL)-PROPIONIC ACID;3-AMINO-3-(2-BROMOPHENYL)PROPANOIC ACID;3-AMINO-3-(2-BROMO-PHENYL)-PROPIONIC ACID;3-(2-BROMOPHENYL)-BETA-ALANINE;2-AMINO-3-METHYLQUINOLINE HYDROCHLORIDE
• CAS NO: 117391-48-7
• Molecular Formula: C₉H₁₀BrNO₂
• Molecular Weight: 244.09
• Product Categories: B-Amino
• Mol File: 117391-48-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 221-223°C
• Boiling Point: 366.834 °C at 760 mmHg
• Flash Point: 175.655 °C
• Appearance: /
• Density: 1.585 g/cm³
• Vapor Pressure: 5E-06mmHg at 25°C
• Refractive Index: 1.607
• PKA: 3.62±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-3-METHYLQUINOLINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-3-METHYLQUINOLINE HYDROCHLORIDE(117391-48-7)
• EPA Substance Registry System: 2-AMINO-3-METHYLQUINOLINE HYDROCHLORIDE(117391-48-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 117391-48-7(Hazardous Substances Data)

Usage

General Description

2-Amino-3-methylquinoline hydrochloride is a chemical compound that belongs to the quinoline family. It is a yellow to orange crystalline solid that is soluble in water. 2-AMINO-3-METHYLQUINOLINE HYDROCHLORIDE is commonly used as a precursor in the synthesis of various pharmaceuticals and organic compounds. It is also used in the manufacture of dyes and pigments. In addition, 2-amino-3-methylquinoline hydrochloride has been studied for its potential anti-cancer and anti-inflammatory properties, making it a valuable compound in the field of medicinal chemistry.

InChI:InChI=1/C9H10BrNO2/c10-7-4-2-1-3-6(7)8(11)5-9(12)13/h1-4,8H,5,11H2,(H,12,13)/t8-/m1/s1

Upstream product

• 141-82-2 malonic acid 
• 6630-33-7 ortho-bromobenzaldehyde 

Downstream Products

• 284493-55-6 3-(2-bromophenyl)-3-[(tert-butoxycarbonyl)amino]propanoic acid 
• 1213854-52-4 C₁₀H₁₂BrNO₂ 
• 1340537-22-5 C₁₁H₁₂BrNO₃ 
• 1426822-65-2 C₁₃H₁₃BrF₃NO₃ 
• 117291-28-8 3-(2-Bromo-phenyl)-3-(2,2,2-trifluoro-acetylamino)-propionyl chloride 
• 737751-95-0 (S)-3-amino-3-(2-bromophenyl)propionic acid 
• 117291-11-9 3-(2-bromophenyl)-3-trifluoroacetylaminopropanoic acid 

Relevant articles and documents

Synthesis and biological evaluation of 3-phenyl-3-aryl carboxamido propanoic acid derivatives as small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26A1)

All-trans-retinoic acid (ATRA), the biologically active metabolite of vitamin A, is used medicinally for the treatment of hyperproliferative diseases and cancers. However, it is easily metabolized. In this study, the leading compound S8 was found based on virtual screening. To improve the activity of the leading compound S8, a series of novel S8 derivatives were designed, synthesized and evaluated for their in vitro biological activities. All of the prepared compounds showed that substituting the 5-chloro-3-methyl-1-phenyl-1H-pyrazole group for the 2-tertbutyl-5-methylfuran scaffold led to a clear increase in the biological activity. The most promising compound 32, with a CYP26A1 IC50 value of 1.36 μM (compared to liarozole (IC50 = 2.45 μM) and S8 (IC50 = 3.21 μM)) displayed strong inhibitory and differentiation activity against HL60 cells. In addition, the study focused on the effect of β-phenylalanine, which forms the coordination bond with the heme of CYP26A1. These studies suggest that the compound 32 can be used as an appropriate candidate for future development.

Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect

The synthesis of 7-oxo and 7-hydroxy trifluoroallocolchicinoids was achieved through the intramolecular cyclization of o-phenyl-β- phenylalanines. The resulting compounds were evaluated for their cytotoxic activity against KB cells and their inhibitory ef

Une synthese simple des premieres amino-3 indanones-1

The synthesis of various substituted 3-amino-1-indanones was achieved in five steps starting from corresponding benzaldehydes.