1173918-61-0

Basic information

• Product Name: (rac)-methyl 2-(2-azidoacetamido)-3-phenylpropanoate
• CAS NO: 1173918-61-0
• Molecular Weight: 262.268
• Mol File: 1173918-61-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (rac)-methyl 2-(2-azidoacetamido)-3-phenylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (rac)-methyl 2-(2-azidoacetamido)-3-phenylpropanoate(1173918-61-0)
• EPA Substance Registry System: (rac)-methyl 2-(2-azidoacetamido)-3-phenylpropanoate(1173918-61-0)

Safety Data

• Hazardous Substances Data: 1173918-61-0(Hazardous Substances Data)

Upstream product

• 18523-48-3 2-azidoacetic acid 
• 5619-07-8 methyl 2-amino-3-phenylpropanoate hydrochloride 

Downstream Products

• 1174157-98-2 [fac-Mn(CO)3(MeOOCCH(CH₂Ph)NHCOCH₂(N₃C₂H)CH₂OCH₂C(C₃H₃N₂)3)]PF₆ 
• 1372866-70-0 (rac)-tri-tert-butyl 11-((1-(2-((1-methoxy-1-oxo-3-phenylpropan-2-yl)amino)-2-oxo-ethyl)-1H-1,2,3-triazol-4-yl)-methyl)-1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylate 
• 1331753-66-2 bis-([2-(4-((1-(2-(1-methoxy-1-oxo-3-phenylpropan-2-ylamino)-2-oxoethyl)-1H-1,2,3-triazol-4-yl)methoxy)-benzyl)]-cyclopentadienyl) titanium(IV) dichloride 

Relevant articles and documents

Sonogashira and "click" reactions for the N-terminal and side-chain functionalization of peptides with [Mn(CO)3(tpm)] +-based CO releasing molecules (tpm = tris(pyrazolyl)methane)

A recently identified photoactivatable CO releasing molecule (CORM) based on [Mn(CO)3(tpm)]+ was conjugated to functionalized amino acids and model peptides using the Pd-catalyzed Sonogashira cross-coupling and the alkyne-azide 1,3-dipolar cycloaddition ("Click reaction"). Both were found to be fully compatible with all functional groups present. The CORM-peptide conjugates were isolated in reasonable yield and high purity, as indicated by IR spectroscopy, ESI mass spectrometry and RP-HPLC. The myoglobin assay was used to demonstrate that they have CO release properties identical those of the parent compound. This work thus opens the way for a targeted delivery of CORMs to cellular systems.