1174027-14-5Relevant articles and documents
Liposomes containing alkylated methotrexate analogues for phospholipase A2 mediated tumor targeted drug delivery
Kaasgaard, Thomas,Andresen, Thomas L.,Jensen, Simon S.,Holte, Rene O.,Jensen, Lotte T.,Jorgensen, Kent
experimental part, p. 94 - 103 (2010/01/16)
Two lipophilic methotrexate analogues have been synthesized and evaluated for cytotoxicity against KATO III and HT-29 human colon cancer cells. Both analogues contained a C16-alkyl chain attached to the γ-carboxylic acid and one of the analogue