1174043-16-3 Usage
Description
AZD2461 is a phthalazinone derivative and a potential PARP (Poly ADP-ribose Polymerase) inhibitor. It is a compound that has been developed to target and inhibit the activity of PARP enzymes, which play a crucial role in the DNA repair process. By inhibiting PARP, AZD2461 can potentially enhance the effectiveness of DNA-damaging therapies and lead to the death of cancer cells.
Uses
Used in Oncology:
AZD2461 is used as an anticancer agent for targeting PARP enzymes in cancer cells. It is particularly effective against tumors with DNA repair deficiencies, such as those with BRCA mutations. By inhibiting PARP, AZD2461 can lead to the accumulation of DNA damage, ultimately resulting in cell death.
Used in Combination Therapy:
AZD2461 is used in combination with other cancer treatments, such as chemotherapy or radiation therapy, to enhance their effectiveness. The inhibition of PARP by AZD2461 can make cancer cells more susceptible to the DNA-damaging effects of these therapies, leading to improved treatment outcomes.
Used in Drug Development:
AZD2461 serves as a promising candidate for the development of new cancer therapies. Its potential as a PARP inhibitor makes it a valuable compound for further research and development in the field of oncology, with the aim of creating more effective and targeted treatments for various types of cancer.
Used in Preclinical and Clinical Research:
AZD2461 is used as a subject of preclinical and clinical studies to evaluate its safety, efficacy, and potential side effects. These studies are essential for determining the optimal dosage, administration, and treatment regimens for AZD2461, as well as for identifying any potential risks or contraindications associated with its use.
Biochem/physiol Actions
AZD2461, an olaparib analog, is an orally available, potent and selective PARP1 and PARP2 inhibitor that is a poor substrate for drug transporters. AZD2461 exhibits a high efficacy in olaparib-resistant tumors that overexpress P-glycoprotein.
Check Digit Verification of cas no
The CAS Registry Mumber 1174043-16-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,7,4,0,4 and 3 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1174043-16:
(9*1)+(8*1)+(7*7)+(6*4)+(5*0)+(4*4)+(3*3)+(2*1)+(1*6)=123
123 % 10 = 3
So 1174043-16-3 is a valid CAS Registry Number.
1174043-16-3Relevant articles and documents
PHTHALAZINONE COMPOUND
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Page/Page column 7, (2011/02/18)
4-(4-Fluoro-3-(4-methoxypiperidine-1-carbonyl)benzyl)phthalazin-1(2H)-one as crystalline Form C.
