117423-41-3

Basic information

• Product Name: 4-(TERT-BUTYLDIMETHYLSILYLOXYMETHYL)PYRIDINE
• Synonyms: 4-(TERT-BUTYLDIMETHYLSILYLOXYMETHYL)PYRIDINE;AKOS 91359;4-(Dimethyl-tert-butylsilyloxymethyl)pyridine;4-[[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]pyridine;4-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-Pyridine;TBS-4-HydroxyMethylpyridine;Pyridine, 4-[[[(1,1-diMethylethyl)diMethylsilyl]oxy]Methyl]-;4-(tert-butyldimethylsiloxy)methyl pyridine
• CAS NO: 117423-41-3
• Molecular Formula: C₁₂H₂₁NOSi
• Molecular Weight: 223.39
• Product Categories: Pyridine;Aromatics;Miscellaneous Reagents
• Mol File: 117423-41-3.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 271.495 °C at 760 mmHg
• Flash Point: 117.997 °C
• Appearance: /
• Density: 0.93 g/cm³
• Vapor Pressure: 0.011mmHg at 25°C
• Refractive Index: 1.474
• Storage Temp.: 2-8°C
• Solubility: Acetone, Chloroform, Methanol
• PKA: 5.03±0.10(Predicted)
• CAS DataBase Reference: 4-(TERT-BUTYLDIMETHYLSILYLOXYMETHYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(TERT-BUTYLDIMETHYLSILYLOXYMETHYL)PYRIDINE(117423-41-3)
• EPA Substance Registry System: 4-(TERT-BUTYLDIMETHYLSILYLOXYMETHYL)PYRIDINE(117423-41-3)

Safety Data

• Hazardous Substances Data: 117423-41-3(Hazardous Substances Data)

Usage

Description

4-(TERT-BUTYLDIMETHYLSILYLOXYMETHYL)PYRIDINE is a protected pyridine alcohol derivative, commonly used as a synthetic reagent in various chemical reactions. It is characterized by its pale yellow oil appearance.

Uses

Used in Chemical Synthesis:
4-(TERT-BUTYLDIMETHYLSILYLOXYMETHYL)PYRIDINE is used as a synthetic reagent for the protection of pyridine alcohols during chemical reactions. This protection allows for selective reactions to occur at other sites on the molecule, facilitating the synthesis of complex organic compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-(TERT-BUTYLDIMETHYLSILYLOXYMETHYL)PYRIDINE is used as a key intermediate in the synthesis of various drug molecules. Its ability to protect pyridine alcohols makes it a valuable component in the development of new medications with specific therapeutic properties.
Used in Research and Development:
4-(TERT-BUTYLDIMETHYLSILYLOXYMETHYL)PYRIDINE is also utilized in research and development settings for the exploration of new chemical reactions and the synthesis of novel compounds with potential applications in various fields, such as materials science, agrochemicals, and more.

InChI:InChI=1/C12H21NOSi/c1-12(2,3)15(4,5)14-10-11-6-8-13-9-7-11/h6-9H,10H2,1-5H3

Upstream product

• 586-95-8 pyridine-4-methanol 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 342435-03-4 C₁₉H₂₅Cl₂NO₂Si 
• 152122-41-3 2-(tert-butyldimethyl-silyloxy)-1-(4-fluorophenyl)-2-pyridin-4-yl-ethanone 
• 317335-16-3 methyl 4-(bromomethyl)picolinate 
• 317335-15-2 methyl 4-(hydroxymethyl)pyridine-2-carboxylate 
• 119646-48-9 4-hydroxymethyl-2-pyridinecarboxamide 
• 923169-37-3 4-(hydroxymethyl)pyridine-2-carboxylic acid 
• 215307-20-3 6?amino?2?(4?fluorophenyl)?4?benzyloxy?3?(4?pyridyl)?1H-pyrrolo[2,3?b]pyridine 
• 33974-27-5 phenyl(pyridin-4-yl)methanol 
• 1520090-01-0 4-(((tert-butyldimethylsilyl)oxy)(phenyl)methyl)pyridine 
• 1313723-47-5 6-(4-fluorophenyl)-1-(pyrazolo[1,5-a]pyridin-5-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazine 
• 1313727-03-5 pyrazolo[1,5-a]pyridin-5-ylmethanamine 

Relevant articles and documents

A convenient synthesis of cis-4-(sulfomethyl)-piperidine-2-carboxylic acid: NMR assignment

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MATRIX METALLOPROTEINASE (MMP) INHIBITORS AND METHODS OF USE THEREOF

Hydantoin based compounds useful as inhibitors of matrix metalloproteinases (MMPs), particularly macrophage elastase (MMP-12) are described. Also described are related compositions and methods of using the compounds to inhibit MMP-12 and treat diseases mediated by MMP-12, such as asthma, chronic obstructive pulmonary disease (COPD), emphysema, acute lung injury, idiopathic pulmonary fibrosis (IPF), sarcoidosis, systemic sclerosis, liver fibrosis, nonalcoholic steatohepatitis (NASH), arthritis, cancer, heart disease, inflammatory bowel disease (IBD), acute kidney injury (AKI), chronic kidney disease (CKD), Alport syndrome, and nephritis.

Discovery of (S)-1-(1-(Imidazo[1,2- a ]pyridin-6-yl)ethyl)-6-(1-methyl-1 H -pyrazol-4-yl)-1 H -[1,2,3]triazolo[4,5- b ]pyrazine (Volitinib) as a Highly Potent and Selective Mesenchymal-Epithelial Transition Factor (c-Met) Inhibitor in Clinical Development for Treatment of Cancer

HGF/c-Met signaling has been implicated in human cancers. Herein we describe the invention of a series of novel triazolopyrazine c-Met inhibitors. The structure-activity relationship of these compounds was investigated, leading to the identification of compound 28, which demonstrated favorable pharmacokinetic properties in mice and good antitumor activities in the human glioma xenograft model in athymic nude mice.