1174337-28-0

Basic information

• Product Name: 5-(butoxymethyl)-3-phenyloxazolidin-2-one
• Synonyms: 5-(butoxymethyl)-3-phenyloxazolidin-2-one
• CAS NO: 1174337-28-0
• Molecular Weight: 249.31
• Mol File: 1174337-28-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 338.8±11.0 °C(Predicted)
• Density: 1.108±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 5-(butoxymethyl)-3-phenyloxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(butoxymethyl)-3-phenyloxazolidin-2-one(1174337-28-0)
• EPA Substance Registry System: 5-(butoxymethyl)-3-phenyloxazolidin-2-one(1174337-28-0)

Safety Data

• Hazardous Substances Data: 1174337-28-0(Hazardous Substances Data)

Upstream product

• 2426-08-6 glycidyl n-butyl ether 
• 124-38-9 carbon dioxide 
• 62-53-3 aniline 
• 616-38-6 carbonic acid dimethyl ester 

Relevant articles and documents

Bifunctional organocatalysts for the conversion of CO2, epoxides and aryl amines to 3-aryl-2-oxazolidinones

A route to synthesize 3-aryl-2-oxazolidinones is developed, which is achieved through a three component reaction between CO2, aryl amines, and epoxides with a binary organocatalytic system composed of organocatalysts and DBU (1,8-diazabicyclo[5.4.0]undec-7-ene). The method allows wide scopes of epoxide and aryl amine substrates with various functional groups under mild reaction conditions. The control experiments indicate that a cyclic carbonate is formed via cycloaddition of epoxides with CO2, which further reacts with the β-amino alcohol originating from epoxides and aryl amines, resulting in the formation of 3-aryl-2-oxazolidinones finally.

Conversion of Carbon Dioxide into Oxazolidinones Mediated by Quaternary Ammonium Salts and DBU

A straightforward method to construct oxazolidinones through a three-component reaction involving CO2, epoxides, and amines promoted by a combination of Bu4NI and 1,8-diazabicyclo[5.4.0]undec-7-ene was developed. A wide range of aromatic and aliphatic amines and monosubstituted epoxides were converted into 3,5-disubstituted-2-oxazolidines in up to 95 % yield. This metal-free and easily available catalytic system was applicable to a broad range of substrates, including conventionally challenging ones such as aliphatic epoxides, at atmospheric pressure. Preliminary mechanistic studies suggested a reaction pathway involving β-amino alcohols.

3,5-SUBSTITUTED-1,3-OXAZOLIDIN-2-ONE DERIVATIVES

The present invention is directed to 3,5-disubstituted-l,3-oxazolidin~2-one derivatives which are potentiators of metabotropic glutamate receptors, including the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psyc