1174638-52-8

Basic information

• Product Name: N-benzyl-4-methyl-N-(prop-1-yn-1-yl)benzenesulfonamide
• Synonyms: N-benzyl-4-methyl-N-(prop-1-yn-1-yl)benzenesulfonamide
• CAS NO: 1174638-52-8
• Molecular Weight: 299.393
• Mol File: 1174638-52-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: N-benzyl-4-methyl-N-(prop-1-yn-1-yl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-4-methyl-N-(prop-1-yn-1-yl)benzenesulfonamide(1174638-52-8)
• EPA Substance Registry System: N-benzyl-4-methyl-N-(prop-1-yn-1-yl)benzenesulfonamide(1174638-52-8)

Safety Data

• Hazardous Substances Data: 1174638-52-8(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 98-59-9 p-toluenesulfonyl chloride 
• 312329-82-1 N-(2,2-dichlorovinyl)-N-benzyl-4-methyl-benzenesulfonamide 
• 74-88-4 methyl iodide 
• 312329-77-4 N-benzyl-N-formyl-4-methyl-benzenesulfonamide 
• 2003-82-9 3-bromo-2-propyne 
• 1576-37-0 N-benzyl-p-toluenesulfonamide 
• 13195-80-7 1,1-dibromopropene 

Relevant articles and documents

Highly Selective Syn Addition of 1,3-Diones to Internal Ynamides Catalyzed by Zinc Iodide

1,3-Diones are already established as nucleophiles to perform additions to ynamides; the highly selective hydroalkoxylation of internal ynamides is now described. Several catalytic systems have been compared to perform this transformation, including transition-metal-based catalysts and Lewis acids. ZnI2 was found to be both very active and highly selective providing only E adducts through a syn addition. Investigation of the scope and limitations showed that this catalyst was compatible with various functional groups. In addition to seventeen examples of ynamide hydroalkoxylation, one example of ynamide hydroarylation is reported.

Synthesis of Highly Functionalized 4-Aminoquinolines

A diverse set of highly substituted 4-aminoquinolines was synthesized from ynamides, triflic anhydride, 2-chloropyridine, and readily accessible amides in a mild one-step procedure. Diverse products: Electrophilically activated amides easily react with sulfonyl ynamides to yield a diverse range of substituted 4-aminoquinolines. The ynamides can be easily modified by Sonogashira processes or generated from dichloroenamide precursors. Any substituent can thus be introduced at the C3 position of the quinoline. 2-ClPy=2-chloropyridine, Tf2O=triflic anhydride.

Copper-mediated selective cross-coupling of 1,1-dibromo-1-alkenes and heteronucleophiles: Development of general routes to heterosubstituted alkynes and alkenes

Efficient and general procedures for the cross-coupling of 1,1-dibromoalkenes and N-, O-, and P-nucleophiles are reported. Fine-tuning of the reaction conditions allows for either site-selective, double, or alkynylative cross-coupling, therefore providing