1174758-95-2

Basic information

• Product Name: ethyl 5-hydroxy-2-(methylthio)benzofuran-3-carboxylate
• Synonyms: ethyl 5-hydroxy-2-(methylthio)benzofuran-3-carboxylate
• CAS NO: 1174758-95-2
• Molecular Weight: 252.291
• Mol File: 1174758-95-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 5-hydroxy-2-(methylthio)benzofuran-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 5-hydroxy-2-(methylthio)benzofuran-3-carboxylate(1174758-95-2)
• EPA Substance Registry System: ethyl 5-hydroxy-2-(methylthio)benzofuran-3-carboxylate(1174758-95-2)

Safety Data

• Hazardous Substances Data: 1174758-95-2(Hazardous Substances Data)

Upstream product

• 19606-92-9 ethyl 3,3-bismethylthio-2-propenoate 
• 106-51-4 p-benzoquinone 

Downstream Products

• 4610-75-7 5-hydroxyl‐2‐phenylbenzofuran-3-carboxylate ethyl ester 

Relevant articles and documents

Copper(II) bromide/boron trifluoride etherate-cocatalyzed cyclization of ketene dithioacetals and p-quinones: a mild and general approach to polyfunctionalized benzofurans

A new application of copper(II) bromideactivated ketene dithioacetals as nucleophiles in organic chemistry has been developed. Under the cocatalysis of copper(II) bromide (2.0 mol%) and boron trifluoride etherate (10 mol%), the conjugate addition and sequential cyclization of a-electron-withdrawing group-substituted ketene dithioacetals with p-quinones in acetonitrile at room temperature gave a variety of benzofurans. This formal [3 + 2] cycloaddition provides a general method for catalytic synthesis of polyfunctionalized benzofurans with the ad-vantages of readily available starting materials, cheap catalysts, mild reaction conditions, good yields and wide range of synthetic potential for the benzofuran products. Further transformations of the resulting benzofurans to 2-aminobenzofurans and benzofuro[2,3-d]pyrimidine derivatives are also investigated.