117527-56-7Relevant articles and documents
Synthesis of congeners and prodrugs. 3. Water-soluble prodrugs of taxol with potent antitumor activity
Deutsch,Glinski,Hernandez,Haugwitz,Narayanan,Suffness,Zalkow
, p. 788 - 792 (2007/10/02)
Taxol has shown good in vivo antitumor activity in a number of test systems. The formulation of taxol for antitumor testing has been difficult. Esterification at either C-2' or C-7 resulted in loss of in vitro tubulin assembly activity but not cytotoxicit