117538-84-8Relevant articles and documents
Compartmentalization of incompatible reagents within Pickering emulsion droplets for one-pot cascade reactions
Yang, Hengquan,Fu, Luman,Wei, Lijuan,Liang, Jifen,Binks, Bernard P.
, p. 1362 - 1371 (2015)
It is a dream that future synthetic chemistry can mimic living systems to process multistep cascade reactions in a one-pot fashion. One of the key challenges is the mutual destruction of incompatible or opposing reagents, for example, acid and base, oxidants and reductants. A conceptually novel strategy is developed here to address this challenge. This strategy is based on a layered Pickering emulsion system, which is obtained through lamination of Pickering emulsions. In this working Pickering emulsion, the dispersed phase can separately compartmentalize the incompatible reagents to avoid their mutual destruction, while the continuous phase allows other reagent molecules to diffuse freely to access the compartmentalized reagents for chemical reactions. The compartmentalization effects and molecular transport ability of the Pickering emulsion were investigated. The deacetalization-reduction, deacetalization-Knoevenagel, deacetalization-Henry and diazotization-iodization cascade reactions demonstrate well the versatility and flexibility of our strategy in processing the one-pot cascade reactions involving mutually destructive reagents. (Figure Presented).
Selective One-Pot Two-Step C?C Bond Formation using Metal–Organic Frameworks with Mild Basicity as Heterogeneous Catalysts
Cirujano, Francisco G.,López-Maya, Elena,Rodríguez-Albelo, Marleny,Barea, Elisa,Navarro, Jorge A. R.,De Vos, Dirk E.
, p. 4019 - 4023 (2017)
Copper-ion-exchanged nickel pyrazolate frameworks behave as selective heterogeneous catalysts for the one-pot, two-step (Henry reaction/Michael type addition) synthesis of neuroactive pharmaceutical intermediates starting from nitromethane and benzaldehyde. Tuning the basicity of multifunctional metal–organic framework catalysts through ion exchange with copper(II) cations allows the tandem C?C bond-forming process to be selectively directed towards the desired pharmaceutical intermediate.
Base-catalyzed reactions enhanced by solid acids: Amine-catalyzed nitroaldol (Henry) reactions enhanced by silica gel or mesoporous silica SBA-15
Tanemura, Kiyoshi,Suzuki, Tsuneo
supporting information, p. 392 - 396 (2017/12/28)
The reactions of various aldehydes with CH3NO2 catalyzed by Et3N, n-C6H13NH2, and Me2N(CH2)2NH2 were accelerated by the addition of silica gel to give aromatic (aliphatic) β-nitroalcohols, aromatic nitroalkenes, and aromatic 1,3-dinitroalkanes, respectively. Mesoporous silica SBA-15 showed higher activity than silica gel for the synthesis of aromatic nitroalkenes by the reactions of the corresponding aldehydes with CH3NO2 catalyzed by n-C6H13NH2.
Tunable acid-base bifunctional catalytic activity of FeOOH in an orthogonal tandem reaction
Vernekar,Jagadeesan
, p. 4029 - 4038 (2015/08/03)
In this report, we have explored the acid-base bifunctional catalytic activity of iron oxohydroxides (FeOOH) by catalyzing deacetalization and Henry condensation reactions successively in a single pot. The crystalline polymorphs of FeOOH, namely goethite (α FeOOH), akaganite (β FeOOH), lepidocrocite (γ FeOOH) and δ FeOOH, were chemically prepared and tested for the catalytic activity. All the polymorphs of FeOOH exhibited acid-base bifunctional catalytic activity. The relative selectivity for products varied with the polymorphs of FeOOH. Whereas α FeOOH produced benzaldehyde in high yield, the polymorphs β FeOOH, γ FeOOH and δ FeOOH showed high selectivity for trans-β-nitrostyrene. In addition, β FeOOH also exhibited a unique activity towards the formation of 1,3-dinitro-2-phenylpropane. The difference in the catalytic activity of FeOOH polymorphs was explained based on the strength and density of acidic and basic active sites on the surface. Selectivity for the products was tuned by changing the synthesis parameters of the catalysts and reaction conditions.
