1177494-18-6

Basic information

• Product Name: DEXTROMETHORPHAN N-OXIDE
• Synonyms: DEXTROMETHORPHAN N-OXIDE;(9S,13S,14S)-3-Methoxy-17-MethylMorphinan 17-Oxide;(9α,13α,14α)-3-Methoxy-17-MethylMorphinan 17-Oxide
• CAS NO: 1177494-18-6
• Molecular Formula: C18H26ClNO2
• Molecular Weight: 323.85754
• Product Categories: Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 1177494-18-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• PKA: 5.13±0.20(Predicted)
• CAS DataBase Reference: DEXTROMETHORPHAN N-OXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: DEXTROMETHORPHAN N-OXIDE(1177494-18-6)
• EPA Substance Registry System: DEXTROMETHORPHAN N-OXIDE(1177494-18-6)

Safety Data

• Hazardous Substances Data: 1177494-18-6(Hazardous Substances Data)

Usage

Description

Dextromethorphan N-oxide is a pale yellow solid that is an N-oxide derivative of dextromethorphan, a widely used antitussive agent. It is known for its potential applications in the synthesis of various pharmaceutical compounds.

Uses

Used in Pharmaceutical Industry:
Dextromethorphan N-oxide is used as an intermediate in the synthesis of (+)-morphinan N-oxides, which are important compounds in the development of new drugs with potential therapeutic applications.
Used in Chemical Research:
As a pale yellow solid, dextromethorphan N-oxide can be utilized in chemical research for studying the properties and reactivity of N-oxide compounds, contributing to the advancement of organic chemistry and drug discovery.

Upstream product

• 125-70-2 rac-3-methoxy-17-methyl-morphinane 
• 6700-34-1 dextromethorphan hydrobromide, monohydrate 
• 125-71-3 dextromethorphan 

Relevant articles and documents

Preparation method of dextromethorphan hydrobromide oxynitride impurity (by machine translation)

The invention discloses a preparation method of a compound represented by dextromethorphan hydrobromide impurity type I. The dextromethorphan hydrobromide impurity type I preparation method comprises the following steps: dissolving dextromethorphan hydrobromide in water, carrying out free extraction with a base, extracting, and reacting under the action of an oxidizing agent by using an organic solvent to obtain the compound . the method comprises the following steps: dissolving dextromethorphan hydrobromide in water. The preparation method is convenient to operate, mild and controllable in reaction conditions, high in reaction stability, high in reaction product yield, and high in purity. (by machine translation)

Selectivities in the oxidation of tertiary amines and pyridine derivatives by perfluoro cis-2,3-dialkyloxaziridines

When tertiary amines 1 are reacted with perfluoro cis-2,3- dialkyloxaziridines 2 at -60 °C corresponding N-oxides 3 are formed in high yields. The process is chemoselective and diastereoselective. The chemoselectivity in the reaction of alkenyl substituted pyridines is solvent dependent, attack occurring exclusively at the carbon-carbon double bond or at the nitrogen atom under protic and aprotic conditions, respectively. Lower selectivities were obtained when standard reagents were used.