117782-76-0

Basic information

• Product Name: Pyrazolo[1,5-a]pyridin-3-ylmethanol
• Synonyms: Pyrazolo[1,5-a]pyridin-3-ylmethanol;(H-pyrazolo[1,5-a]pyridin-3-yl)Methanol
• CAS NO: 117782-76-0
• Molecular Formula: C₈H₈N₂O
• Molecular Weight: 148.16
• Mol File: 117782-76-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 44-46 °C
• Appearance: /
• Density: 1.267g/cm³
• Refractive Index: 1.641
• PKA: 14.08±0.10(Predicted)
• CAS DataBase Reference: Pyrazolo[1,5-a]pyridin-3-ylmethanol(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrazolo[1,5-a]pyridin-3-ylmethanol(117782-76-0)
• EPA Substance Registry System: Pyrazolo[1,5-a]pyridin-3-ylmethanol(117782-76-0)

Safety Data

• Hazardous Substances Data: 117782-76-0(Hazardous Substances Data)

Usage

General Description

Pyrazolo[1,5-a]pyridin-3-ylmethanol is a chemical compound with a pyrazole and pyridine ring structure, substituted with a methanol group. It is often used as a building block in the synthesis of various pharmaceutical and agrochemical compounds. The pyrazole and pyridine rings confer unique reactivity and biological activity, making pyrazolo[1,5-a]pyridin-3-ylmethanol a valuable intermediate for the development of new drugs and biologically active molecules. Its versatile reactivity and potential therapeutic properties make it an important compound in the field of medicinal chemistry.

InChI:InChI=1/C8H8N2O/c11-6-7-5-9-10-4-2-1-3-8(7)10/h1-5,11H,6H2

Upstream product

• 63237-84-3 methyl pyrazolo<1,5-a>pyridine-3-carboxylate 
• 127717-33-3 bis<(pyrazolo<1,5-a>pyrid-3-yl)methyl> ether 
• 16205-44-0 Pyrazolo<1,5-a>pyridin-3-carbonsaeureethylester 

Downstream Products

• 307308-03-8 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carbaldehyde 
• 73957-66-1 3-pyrazolo<1,5-a>pyridineacarboxaldehyde 
• 117782-75-9 (R)-(+)-2-Amino-3-(pyrazolo<1,5-a>pyridin-3-yl)propionsaeure 
• 117782-75-9 (S)-(-)-2-Amino-3-(pyrazolo<1,5-a>pyridin-3-yl)propionsaeure 
• 117782-75-9 2-Amino-3-(pyrazolo<1,5-a>pyridin-3-yl)propionsaeure 
• 117782-82-8 2-(Diphenylmethylenamino)-3(pyrazolo<1,5-a>pyridin-3-yl)propionsaeureethylester 
• 118055-01-9 pyrazolo[1,5-a]pyridin-3-yl-acetonitrile 
• 118054-99-2 3-Pyrazolo<1,5-a>pyridylmethylamin 

Relevant articles and documents

SUBSTITUTED PYRIDIZINONE DERIVATIVES AS PDE10 INHIBITORS

The present invention is directed to substituted pyridizinone compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.

IMIDAZOTRIAZINONE COMPOUNDS

The present invention provides imidazotriazinone compounds which are inhibitors of phosphodiesterase 9 and pharmaceutically acceptable salt thereof. The present invention further provides processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of PDE9 associated diseases or disorders in mammals, including humans.

Acid-Catalyzed Reactions of 3-(Hydroxymethyl)- and 3-(1-Hydroxyethyl)pyrazolopyridines

Treatment of 3-(hydroxymethyl)pyrazolopyridines with trifluoroacetic acid in refluxing dichloromethane led to the formation of bis(pyrazolopyrid-3-yl)methanes or bis pyrid-3-yl)>methyl ethers depending upon the concentration of trifluoroacetic acid.In contrast, similar treatment of 3-(1-hydroxyethyl)pyrazolopyridines gave a mixture of 3-vinylpyrazolopyridines and 1,3-bis(pyrazolopyrid-3-yl)-1-butenes.