1177848-21-3

Basic information

• Product Name: (2E)-(2-benzylidene)-4-(3,4-dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-one
• Synonyms: (2E)-(2-benzylidene)-4-(3,4-dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-one
• CAS NO: 1177848-21-3
• Molecular Weight: 379.285
• Mol File: 1177848-21-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2E)-(2-benzylidene)-4-(3,4-dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-(2-benzylidene)-4-(3,4-dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-one(1177848-21-3)
• EPA Substance Registry System: (2E)-(2-benzylidene)-4-(3,4-dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-one(1177848-21-3)

Safety Data

• Hazardous Substances Data: 1177848-21-3(Hazardous Substances Data)

Upstream product

• 79560-19-3 4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one 
• 100-52-7 benzaldehyde 

Downstream Products

• 1227614-55-2 C₂₄H₁₈Cl₂N₂S 
• 1227614-65-4 6-(3,4-dichlorophenyl)-2-oxo-4-phenyl-1,2,4a,5,6,10b-hexahydrobenzo[h]quinoline-3-carbonitrile 
• 1333478-80-0 C₂₉H₂₂Cl₂N₂ 
• 1333478-70-8 6-(3,4-dichlorophenyl)-4-phenyl-5,6-dihydrobenzo[h]quinazolin-2-amine 

Relevant articles and documents

Synthesis of some amino-pyrimidines and pyrazolines as potent antimicrobial agents

Base catalysed condensation of ketone (1) with different aromatic aldehydes afforded chalcones (2E)-2-arylidene-4-(3,4-dichlorophenyl)-3,4- dihydronaphthalen-1(2H)-ones (2a-j). These chalcones on cyclization with guanidine hydrochloride in the presence of few drops of sodium hydroxide in abs alcohol resulted in the formation of 2-amino-4-aryl-6-(3,4-dichlorophenyl)-5,6- dihydrobenzo [h] pyrimidines (3a-j). The cyclocondensation of 2a-j with phenyl hydrazine in the presence of triethylamine in abs alcohol yielded 3-aryl-5-(3,4-dichlorophenyi)-2-phenyl-3. 3a, 4,5-tetrahydro-2H-benzo [g] pyrazolines (4a-j). The structures of new compounds have been established by spectroscopic and elemental analysis. The new compounds have been tested for their antimicrobial activity.