1178587-02-4Relevant articles and documents
A modular approach to synthetic RNA binders of the hepatitis C virus internal ribosome entry site
Carnevali, Maia,Parsons, Jerod,Wyles, David L.,Hermann, Thomas
, p. 1364-1367+1315 (2011/04/24)
(Figure Presented) DAPper ligands: The 3,5-diaminopiperidine (DAP) heterocycle has been developed as a structural mimetic of the RNA-recognizing pharmacophore of the 2-DOS scaffold. Here we describe the synthesis of novel modular DAP ligands that bind to a conformational target in the internal ribosome entry site RNA of the hepatitis C virus.