117872-75-0 Usage
Description
Fmoc-THr(Bzl)-OH, also known as N-(9-fluorenylmethoxycarbonyl)-O-benzyl-L-threonine, is a protected amino acid derivative commonly used in the field of peptide synthesis. It is characterized by the presence of the Fmoc (9-fluorenylmethoxycarbonyl) protecting group and a benzyl (Bzl) group, which protect the amino and hydroxyl functional groups, respectively. Fmoc-THr(Bzl)-OH plays a crucial role in the stepwise assembly of peptides through solid-phase peptide synthesis (SPPS) techniques.
Uses
Used in Pharmaceutical Industry:
Fmoc-THr(Bzl)-OH is used as a building block for the synthesis of various therapeutic peptides, including thrombospondin-1 (TSR2) and its associated peptide fragments. These peptides have potential applications in the treatment of various diseases and disorders, such as cancer, inflammation, and vascular diseases, due to their ability to modulate cellular processes and interactions.
Used in Research and Development:
In the field of research and development, Fmoc-THr(Bzl)-OH is utilized as a key component in the design and synthesis of novel peptide-based drugs and bioactive molecules. Its use in SPPS allows for the creation of a wide range of peptide sequences with specific biological activities, making it a valuable tool for exploring the structure-activity relationships of peptides and identifying potential therapeutic agents.
Used in Diagnostic Applications:
Fmoc-THr(Bzl)-OH can also be employed in the development of diagnostic tools, such as peptide-based assays and sensors, that rely on the specific interactions between peptides and their target molecules. These diagnostic applications can be used to detect and monitor various diseases and conditions, as well as to study the underlying biological processes involved.
Check Digit Verification of cas no
The CAS Registry Mumber 117872-75-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,7,8,7 and 2 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 117872-75:
(8*1)+(7*1)+(6*7)+(5*8)+(4*7)+(3*2)+(2*7)+(1*5)=150
150 % 10 = 0
So 117872-75-0 is a valid CAS Registry Number.
InChI:InChI=1/C26H25NO5/c1-17(31-15-18-9-3-2-4-10-18)24(25(28)29)27-26(30)32-16-23-21-13-7-5-11-19(21)20-12-6-8-14-22(20)23/h2-14,17,23-24H,15-16H2,1H3,(H,27,30)(H,28,29)/t17-,24+/m1/s1
117872-75-0Relevant articles and documents
2,2-Difluoro-1,3,2-oxazaborolidin-5-ones: Novel approach for selective side-chain protection of serine and threonine
Wang, Jidong,Okada, Yoshio,Li, Wei,Yokoi, Toshio,Zhu, Jintao
, p. 621 - 624 (1997)
2,2-Difluoro-1,3,2-oxazaborolidin-5-ones 1, which are synthesized from BF3 and salts of amino acids, are highly effective, convenient and, moreover, inexpensive intermediates for the simultaneous protection of both α-amino and α-carboxy groups in α-amino acids. The new method streamlines the hitherto tedious procedures for side-chain protection of Ser and Thr. Ser(Bu′), Thr(Bu′), Ser(Bzl) and Thr(Bzl) are obtained by this procedure in high yields and in pure form using highly reactive reagents.
