117874-51-8Relevant articles and documents
Synthesis and biological evaluation of new 4-carboxyl quinoline derivatives as cyclooxygenase-2 inhibitors
Zarghi, Afshin,Ghodsi, Razieh,Azizi, Ebrahim,Daraie, Bahram,Hedayati, Mehdi,Dadrass, Orkideh G.
experimental part, p. 5312 - 5317 (2009/10/17)
A group of 4-carboxyl quinoline derivatives possessing a methylsulfonyl COX-2 pharmacophore at the para position of the C-2 phenyl ring were designed and synthesized as selective COX-2 inhibitors. In vitro COX-1/COX-2 structure-activity relationships were
