117886-49-4

Basic information

• Product Name: Phenol, 4-amino-2-methyl-5-(1-methylethyl)- (9CI)
• Synonyms: Phenol, 4-amino-2-methyl-5-(1-methylethyl)- (9CI)
• CAS NO: 117886-49-4
• Molecular Formula: C₁₀H₁₅NO
• Molecular Weight: 165.2322
• Product Categories: ISOPROPYL
• Mol File: 117886-49-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Phenol, 4-amino-2-methyl-5-(1-methylethyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 4-amino-2-methyl-5-(1-methylethyl)- (9CI)(117886-49-4)
• EPA Substance Registry System: Phenol, 4-amino-2-methyl-5-(1-methylethyl)- (9CI)(117886-49-4)

Safety Data

• Hazardous Substances Data: 117886-49-4(Hazardous Substances Data)

Upstream product

• 499-75-2 carvacrol 
• 7664-93-9 sulfuric acid 
• 41364-29-8 4-nitrosocarvacrol 
• 100-63-0 phenylhydrazine 
• 71-43-2 benzene 

Downstream Products

• 130767-00-9 ethyl 2-<2-(1-methylethyl)-4-hydroxy-5-methylphenylcarbamoyl>-butanoate 
• 130767-01-0 N,N'-bis<2-(1-methylethyl)-4-hydroxy-5-methylphenyl>-2-propylpropanediamide 
• 1398572-90-1 1-(2-Cl-benzoyl)-3-(4-hydroxy-2-methyl-5-isopropylphenyl)thiourea 
• 1398572-96-7 1-(2-Cl-benzoyl)-3-(4-hydroxy-2-methyl-5-isopropylphenyl)urea 
• 1398572-99-0 1-(4-F-benzoyl)-3-(4-hydroxy-2-methyl-5-isopropylphenyl)urea 
• 1398572-93-4 1-(4-F-benzoyl)-3-(4-hydroxy-2-methyl-5-isopropylphenyl)thiourea 
• 1398572-89-8 1-benzoyl-3-(4-hydroxy-2-methyl-5-isopropylphenyl)thiourea 
• 1398572-95-6 1-benzoyl-3-(4-hydroxy-2-methyl-5-isopropylphenyl)urea 
• 1398572-91-2 1-(4-Cl-benzoyl)-3-(4-hydroxy-2-methyl-5-isopropylphenyl)thiourea 
• 1398572-97-8 1-(4-Cl-benzoyl)-3-(4-hydroxy-2-methyl-5-isopropylphenyl)urea 
• 1398573-00-6 1-(2,6-F-benzoyl)-3-(4-hydroxy-2-methyl-5-isopropylphenyl)urea 
• 1398572-94-5 1-(2,6-F-benzoyl)-3-(4-hydroxy-2-methyl-5-isopropylphenyl)thiourea 
• 1398572-98-9 1-(2-F-benzoyl)-3-(4-hydroxy-2-methyl-5-isopropylphenyl)urea 
• 1398572-92-3 1-(2-F-benzoyl)-3(4-hydroxy-2-methyl-5-isopropylphenyl)thiourea 

Relevant articles and documents

Synthesis, characterizations, biological activities and docking studies of novel dihydroxy derivatives of natural phenolic monoterpenoids containing azomethine linkage

Abstract: In the present work, we report the synthesis of six new azomethine linkage containing dihydroxy derivatives of carvacrol, thymol, and eugenol. All the synthesized derivatives have been characterized by spectroscopic techniques and their structures were confirmed by X-ray single crystallography. Synthesized derivatives were screened for anti-oxidant activity using DPPH radical scavenging assay, and anticancer activity by using SRB assay against pancreatic cancer with MIAPaCa-2 and colon cancer with HCT-15 cell lines. The molecular docking studies of all the synthesized derivatives were performed on cyclooxygenases (COX-2) protein enzyme. In the anti-oxidant test, the values of EC50 indicated that all the compounds show excellent anti-oxidant potency, and similarly the GI50 values in anticancer tests indicated that most of the compounds possess good anticancer efficacy. The overall docking score suggested that all the synthesized compounds exhibit good binding affinity towards cyclooxygenases (COX-2) protein enzyme.

Synthesis and antioxidant activity of thymol and carvacrol based Schiff bases

Thymol and carvacrol are well known antioxidants found in the extract of the plants of thyme species. The Schiff bases of 2-iso-propyl-5-methyl-phenol (thymol/1a), 2-tert-butyl-5-methyl-phenol (1b) and 5-iso-propyl-2-methyl-phenol (carvacrol/1c) exhibited much better antioxidant activity than thymol and carvacrol in DPPH assay. Ten compounds (4k, 4l, 4r, 5k, 5l, 5q, 5r, 6k, 6l and 6r) showed better or similar activity as compared to the reference compound ascorbic acid. Twenty-four most active compounds were also screened by ABTS method and showed 60-90% inhibition at 5 μg/mL concentration.