1178863-97-2Relevant articles and documents
First chemoenzymatic synthesis of immunomodulating macrolactam pimecrolimus
Ferraboschi, Patrizia,Colombo, Diego,De Mieri, Maria,Grisenti, Paride
, p. 4384 - 4388 (2009)
The preparation of pimecrolimus, a synthetic derivative of ascomycin endowed with immunomodulatory activity, requires the selective protection of 24-hydroxy group of the ascomycin, before elaboration of the 32-hydroxy group. The aim was achieved by means