1178884-23-5

Basic information

• Product Name: 2-(3-bromo-phenyl)-3-(3-t-butyl-phenylamino)-acrylic acid ethyl ester
• Synonyms: 2-(3-bromo-phenyl)-3-(3-t-butyl-phenylamino)-acrylic acid ethyl ester
• CAS NO: 1178884-23-5
• Molecular Weight: 402.331
• Mol File: 1178884-23-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(3-bromo-phenyl)-3-(3-t-butyl-phenylamino)-acrylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-bromo-phenyl)-3-(3-t-butyl-phenylamino)-acrylic acid ethyl ester(1178884-23-5)
• EPA Substance Registry System: 2-(3-bromo-phenyl)-3-(3-t-butyl-phenylamino)-acrylic acid ethyl ester(1178884-23-5)

Safety Data

• Hazardous Substances Data: 1178884-23-5(Hazardous Substances Data)

Upstream product

• 5369-19-7 3-tert-butylaniline 
• 220099-03-6 benzyl (3-bromophenyl)-acetate 
• 109-94-4 formic acid ethyl ester 

Downstream Products

• 1178884-25-7 3-(3-bromo-phenyl)-7-tert-butyl-1H-quinolin-4-one 

Relevant articles and documents

Inhibitors of Bruton's Tyrosine Kinase

This application discloses 5-phenyl-1H-pyridin-2-one, 6-phenyl-2H-pyridazin-3-one, and 5-Phenyl-1H-pyrazin-2-one derivatives according to generic Formulae I-III: wherein, variables Q, R, X, X′, Y1, Y2, Y2′, Y3, Y4, Y5, m, and n are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formulae I-III and at least one carrier, diluent or excipient.