117890-46-7

Basic information

• Product Name: 2-aminopiperidine.2HCl
• CAS NO: 117890-46-7
• Molecular Weight: 136.625
• Mol File: 117890-46-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-aminopiperidine.2HCl(CAS DataBase Reference)
• NIST Chemistry Reference: 2-aminopiperidine.2HCl(117890-46-7)
• EPA Substance Registry System: 2-aminopiperidine.2HCl(117890-46-7)

Safety Data

• Hazardous Substances Data: 117890-46-7(Hazardous Substances Data)

Usage

Structure

Consists of a piperidine ring substituted with an amino group at the 2-position, along with two molecules of hydrochloric acid.

Physical State

White crystalline solid

Applications

Used in pharmaceutical and chemical processes
Studied for potential applications in the synthesis of:
Antipsychotic medications
Antihistamines
Utilized in the production of other organic chemicals

Research Focus

Properties and reactions are subjects of ongoing research and development
Particularly in the fields of chemistry and pharmacology

Upstream product

• 73874-95-0 (piperidin-4-yl)carbamic acid tert-butyl ester 

Downstream Products

• 98336-90-4 N-(1-formyl-[4]piperidyl)-formamide 
• 75970-99-9 norastemizole 
• 86589-84-6 1-<2-(4-chlorophenyl)-2-hydroxyethyl>-4-(2-nitrophenylmethyl)aminopiperidine.HCl 
• 86589-82-4 1-(2-phenyl-2-hydroxyethyl)-4-(2-nitrophenylmethyl)aminopiperidine.HCl 
• 86589-85-7 1-<2-(4-chlorophenyl)-2-hydroxyethyl>-4-(2-aminophenylmethyl)aminopiperidine.2HCl 
• 86589-83-5 1-(2-phenyl)-2-hydroxyethyl-4-(2-aminophenylmethyl)aminopiperidine.2HCl 
• 86589-74-4 1-<2-(4-chlorophenyl)-2-hydroxyethyl>-4-(3,4-dihydro-1,2,3-benzotriazin-3-yl)piperidine 
• 86589-73-3 1-(2-phenyl-2-hydroxyethyl)-4-(3,4-dihydro-1,2,3-benzotriazin-3-yl)piperidine 
• 87120-72-7 1-(tert-butoxycarbonyl)-4-aminopiperidine 
• 202198-91-2 N-benzylpiperidin-4-yl-benzylamine 
• 50541-93-0 4-amino-1-benzylpiperidine 
• 33953-37-6 N-(piperidin-4-yl)benzamide 

Relevant articles and documents

Solvent-freeN-Boc deprotection byex situgeneration of hydrogen chloride gas

An efficient, scalable and sustainable method for the quantitative deprotection of thetert-butyl carbamate (N-Boc) protecting group is described, using down to near-stoichiometric amounts of hydrogen chloride gas in solvent-free conditions. We demonstrate theex situgeneration of hydrogen chloride gas from sodium chloride and sulfuric acid in a two-chamber reactor, introducing a straightforward method for controlled and stoichiometric release of HCl gas. The solvent-free conditions allow deprotection of a wide variety ofN-Boc derivatives to obtain the hydrochloride salts in quantitative yields. The procedure obviates the need for any work-up or purification steps providing an uncomplicated green alternative to standard methods. Due to the solvent-free, anhydrous conditions, this method shows high tolerance towards acid sensitive functional groups and furnishes expanded functional group orthogonality.