117896-69-2

Basic information

• Product Name: 1-PHENYLPIPERIDIN-4-OL
• Synonyms: 1-PHENYLPIPERIDIN-4-OL;RARECHEM AH CK 0161;1-Phenylpiperidin-4-ol 98%;1-Phenyl-4-Piperidinol
• CAS NO: 117896-69-2
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.24
• Mol File: 117896-69-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 69-70℃
• Boiling Point: 314 °C at 760 mmHg
• Flash Point: 160.9 °C
• Appearance: /
• Density: 1.116 g/cm³
• Vapor Pressure: 0.000204mmHg at 25°C
• Refractive Index: 1.577
• Storage Temp.: 2-8°C
• PKA: 14.90±0.20(Predicted)
• CAS DataBase Reference: 1-PHENYLPIPERIDIN-4-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PHENYLPIPERIDIN-4-OL(117896-69-2)
• EPA Substance Registry System: 1-PHENYLPIPERIDIN-4-OL(117896-69-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 117896-69-2(Hazardous Substances Data)

Usage

General Description

1-Phenylpiperidin-4-ol, also known as 4-Phenylpiperidin-4-ol, is a chemical compound with the molecular formula C11H15NO. It is a synthetic intermediate that is used in the production of pharmaceuticals, particularly in the synthesis of opioid analgesics such as pethidine and its derivatives. It is a white solid at room temperature and is soluble in organic solvents such as ethanol and diethyl ether. 1-Phenylpiperidin-4-ol is a psychoactive compound that acts as a serotonin and norepinephrine reuptake inhibitor, and it has been studied for its potential in the treatment of depression and other mood disorders.

InChI:InChI=1/C11H15NO/c13-11-6-8-12(9-7-11)10-4-2-1-3-5-10/h1-5,11,13H,6-9H2

Upstream product

• 19125-34-9 1-phenylpiperidin-4-one 
• 62-53-3 aniline 
• 7564-64-9 3-methyl-1,3,5-pentanetriol 
• 71-43-2 benzene 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 591-50-4 iodobenzene 
• 108-86-1 bromobenzene 
• 50-00-0 formaldehyd 
• 13424-22-1 4-(N-methyl-N-phenylamino)-1-butene 
• 198649-62-6 8-phenyl-1,4-dioxa-8-azaspiro[4,5]decane 
• 72548-31-3 1,5-Dichloropentan-3-ol 
• 117896-64-7 But-3-enyl-tert-butylperoxymethyl-phenyl-amine 

Downstream Products

• 943586-14-9 C₁₆H₂₃NO₂ 
• 945682-69-9 methyl N-tert-butoxycarbonyl-O-(1-phenyl-piperidin-4-yl)-L-tyrosinate 
• 186644-66-6 4-Methoxy-1-phenyl-1,2,5,6-tetrahydropyridine 
• 188252-72-4 1-Phenyl-4,4-dimethoxypiperidine 
• 105123-93-1 2'-O-(4-Methoxy-1-phenylpiperidin-4-yl)uridine 
• 19125-34-9 1-phenylpiperidin-4-one 
• 861021-76-3 4-bromo-1-phenyl-piperidine 

Relevant articles and documents

Synthesis method of intermediate N-phenyl-4-piperidone

The invention discloses a synthesis method of an intermediate N-phenyl-4-piperidone, which comprises the following steps: dissolving aniline in diethyl ether, adding a catalyst, adding 3-methyl-1,3,5-pentanetriol under stirring, heating the raw material t

N/O-LINKED DEGRONS AND DEGRONIMERS FOR PROTEIN DEGRADATION

This invention provides Degronimers that have E3 Ubiquitin Ligase targeting moieties (Degrons) that can be linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation. The invention also provides Degrons that can be used to treat disorders mediated by cereblon or an Ikaros family protein, and methods of use and compositions thereof as well as methods for their preparation.

A cascade Aza-Cope/Aza-prins cyclization leading to piperidine derivatives

The cascade aza-Cope/aza-Prins cyclization of homoallylamines to give substituted piperidines has been explored. The use of glyoxalic acid as the carbonyl component afforded bicyclic structures as a result of the internal carboxylate anion trapping the intermediate cation. The unimolecular bis-, tris-, and tetrakis(homoallylamine)s efficiently delivered the appended bis-, tris- and tetrakis(piperidine-4-ol)s (tripod and crucifix shape, respectively) as new entities. The latter compound served as an excellent ligand in the Suzuki-Miyaura cross-coupling reaction to synthesize incrustoporin. The cascade aza-Cope/aza-Prins cyclization of homoallylamines to give substituted piperidines is described. A unimolecular tetrapiperidine derivative, which resulted from this strategy, was employed as a ligand in the Suzuki-Miyaura cross-coupling reaction of an α-iodobutenolide with an arylboronic acid in an efficient synthesis of incrustoporin and its analogues.