117926-09-7

Basic information

• Product Name: 16α-hydroxyl resibufogenin
• CAS NO: 117926-09-7
• Molecular Weight: 400.515
• Mol File: 117926-09-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 16α-hydroxyl resibufogenin(CAS DataBase Reference)
• NIST Chemistry Reference: 16α-hydroxyl resibufogenin(117926-09-7)
• EPA Substance Registry System: 16α-hydroxyl resibufogenin(117926-09-7)

Safety Data

• Hazardous Substances Data: 117926-09-7(Hazardous Substances Data)

Upstream product

• 465-39-4 resibufogenin 

Downstream Products

• 474-53-3 5?[(3S,5R,8R,9S,10S,13S)?3?hydroxy?10,13?di?methyl?2,3,4,5,6,7,8,9,10,11,12,13?dodecahydro?1H?cyclopenta[a]phenanthren?17?yl]?2H?pyran?2?one 

Relevant articles and documents

New cytotoxic bufadienolides from the biotransformation of resibufogenin by Mucor polymorphosporus

Resibufogenin is a cytotoxic steroid isolated from the Chinese drug ChanSu. The biotransformation of resibufogenin by Mucor polymorphosporus afforded 22 products, and 15 of them were new. The transformation reactions involved hydroxylations at C-1β, C-5, C-7α, C-7β, C-12α, C-12β and C-16α, as well as epimerization or dehydrogenation of 3-OH. Hydroxylations at C-12α, C-12β and C-16α were the major reactions, each giving products in >5% yields, whereas the other products were obtained in fairly low yields. Some of the products showed decreased but still potent cytotoxicities. This investigation provided a useful approach to prepare new bufadienolides and most of them were difficult to obtain by chemical means.