1179358-90-7

Basic information

• Product Name: 1-(1-methyl-1H-imidazol-2-yl)-3-phenylpropan-1-one
• Synonyms: 1-(1-methyl-1H-imidazol-2-yl)-3-phenylpropan-1-one
• CAS NO: 1179358-90-7
• Molecular Weight: 214.267
• Mol File: 1179358-90-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-(1-methyl-1H-imidazol-2-yl)-3-phenylpropan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-methyl-1H-imidazol-2-yl)-3-phenylpropan-1-one(1179358-90-7)
• EPA Substance Registry System: 1-(1-methyl-1H-imidazol-2-yl)-3-phenylpropan-1-one(1179358-90-7)

Safety Data

• Hazardous Substances Data: 1179358-90-7(Hazardous Substances Data)

Upstream product

• 1179358-94-1 (E)-1-(1-methyl-1H-imidazol-2-yl)-3-phenylprop-2-en-1-ol 
• 616-47-7 1-methyl-1H-imidazole 
• 2021-28-5 ethyl dihydrocinnamate 
• 99802-91-2 2-cinnamoyl-1-methyl-1H-imidazole 

Downstream Products

• 103-25-3 3-phenylpropanoic acid methyl ester 

Relevant articles and documents

Light-Driven Enantioselective Synthesis of Pyrroline Derivatives by a Radical/Polar Cascade Reaction

Herein, a light-driven, atom-economical process that provides access to enantiomerically enriched substituted chiral 1-pyrroline derivatives is introduced. The strategy involves the distal functionalization of acyl heterocycles through a hydrogen-atom transfer (HAT) process and the use of tailor-made ketimines as reliable electrophilic partners. This transformation is translated into an enantiomerically controlled radical/polar cascade reaction in which water is produced as the sole by-product and stereoselectivity is dictated by coordination to a chiral-at-rhodium catalyst.

Strategy for Catalytic Chemoselective Cross-Enolate Coupling Reaction via a Transient Homocoupling Dimer

A new strategy, a transient homocoupling dimer strategy, for direct catalytic oxidative cross-enolate coupling reactions is developed. Cross-enolate coupling products bearing a (contiguous) tetrasubstituted carbon center were obtained chemoselectively without the need for stoichiometric amounts of strong bases/metal oxidants, and thus, the present catalysis provides a general method for the synthesis of unnatural α,α-disubstituted amino acid motifs. The distinct transformation of azlactone and 2-acylimidazole units highlighted the synthetic utility of the present catalysis.

Aerobic oxidation of secondary benzylic alcohols and direct oxidative amidation of aryl aldehydes promoted by sodium hydride

We reported herein new reactivities and possible mechanistic implications of a simplest oxidant (NaH/air) uncovered on a broad range of useful transformations, including aerobic alcohol oxidations, allylic alcohol isomerizations and oxidations, cyclopropyl alcohol fragmentations, and direct aryl aldehyde oxidative amidations. These readily implementable transition-metal-free processes feature exceptional material accessibility, operational simplicity, and environmental compatibility, and add new dimensions to its synthetic utilities that are fairly robust yet had not previously been fully realized and systematically explored.