117970-24-8

Basic information

• Product Name: 3',4-dimethoxydeoxybenzoin ethylene acetal
• Synonyms: 3',4-dimethoxydeoxybenzoin ethylene acetal
• CAS NO: 117970-24-8
• Molecular Weight: 300.354
• Mol File: 117970-24-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3',4-dimethoxydeoxybenzoin ethylene acetal(CAS DataBase Reference)
• NIST Chemistry Reference: 3',4-dimethoxydeoxybenzoin ethylene acetal(117970-24-8)
• EPA Substance Registry System: 3',4-dimethoxydeoxybenzoin ethylene acetal(117970-24-8)

Safety Data

• Hazardous Substances Data: 117970-24-8(Hazardous Substances Data)

Upstream product

• 100-66-3 methoxybenzene 
• 1798-09-0 m-methoxyphenylacetic acid 
• 107-21-1 ethylene glycol 
• 98540-26-2 1′-(3-methoxyphenyl)-2′-(4′′-methoxyphenyl)ethan-2′-one 

Downstream Products

• 36640-12-7 3-(4-methoxyphenyl)-7-methoxy-2-benzopyran-1(1H)-one 
• 117970-26-0 3',4-dimethoxydeoxybenzoin-2'-carboxylic acid 
• 36640-13-8 methyl 3',4-dimethoxydeoxybenzoin-2'-carboxylate 
• 98540-26-2 1′-(3-methoxyphenyl)-2′-(4′′-methoxyphenyl)ethan-2′-one 
• 480-47-7 hydrangenol 
• 82780-51-6 (+/-)-3-(4-methoxyphenyl)-8-methoxy-3,4-dihydroisocoumarin 

Relevant articles and documents

TOTAL SYNTHESIS OF (+/-)-HYDRANGENOL

The title compound 8 has been synthesized in five steps and in about 33percent overall yield from 3-methoxyphenylacetic acid, 1.Acid 1 was condensed with anisole in polyphosphoric acid to give 3',4-dimethoxydeoxybenzoin, 2, which was converted to the ethylene acetal 3.The latter was metallated with buthyllithium and carbonated giving crude 3',4-dimethoxydeoxybenzoin-2'-carboxylic acid, 4, from which 3,4-dihydro-8-methoxy-3-(4'-methoxyphenyl)isocoumarin, 7, was obtained either by reduction with sodium borohydride and dehydration, or dehydration to 8-methoxy-3-(4'-methoxyphenyl)isocoumarin, 6, and catalytic hydrogenation.Finally, demethylation of 6 to 8 was performed with boron tribromide.