118352-74-2 Usage
Description
Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-(hydrogen phosphonate), compd. with N,N-diethylethanamine (1:1) is a complex chemical compound that consists of cytidine, a nucleoside found in RNA, and N,N-diethylethanamine, a derivative of ethylamine. Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-,
3'-(hydrogen phosphonate), compd. with N,N-diethylethanamine (1:1) also features a benzoyl group and a hydrogen phosphonate group, which contribute to its stability and reactivity. Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-,
3'-(hydrogen phosphonate), compd. with N,N-diethylethanamine (1:1) is primarily used for research purposes and has potential applications in the field of biochemistry and pharmaceutical research, particularly in the study of nucleic acids and their interactions with specific enzymes or proteins. Its unique composition and properties make it a valuable tool for investigating the structure and function of nucleic acids and related biological processes.
Used in Biochemical Research:
Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-(hydrogen phosphonate), compd. with N,N-diethylethanamine (1:1) is used as a research compound for studying the structure and function of nucleic acids and their interactions with specific enzymes or proteins.
Used in Pharmaceutical Research:
Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-(hydrogen phosphonate), compd. with N,N-diethylethanamine (1:1) is used as a pharmaceutical research compound for investigating the potential applications of nucleic acids in drug development and therapeutic interventions.
Check Digit Verification of cas no
The CAS Registry Mumber 118352-74-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,8,3,5 and 2 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 118352-74:
(8*1)+(7*1)+(6*8)+(5*3)+(4*5)+(3*2)+(2*7)+(1*4)=122
122 % 10 = 2
So 118352-74-2 is a valid CAS Registry Number.
118352-74-2Relevant articles and documents
A convenient and efficient method for the synthesis of nucleoside H-phosphonates using a novel phosphonylating agent
Yang,Xu,Shen,Fang
, p. 167 - 173 (1995)
In the present paper we descibe the preparation of a novel crystalline phosphonylating agent 9-fluorenemethyl phosphonic acid 2 and a convenient and efficient method for the synthesis of nucleoside H-phosphonates 5.
The H-phosphonate approach to the synthesis of oligonucleotides and their phosphorothioate analogues in solution
Reese, Colin B.,Quanlai, Song
, p. 1477 - 1486 (2007/10/03)
A new approach to the synthesis of oligonucleotides and oligonucleotide phosphorothioates in solution is described; it is based on H-phosphonate coupling [with bis(2-chlorophenyl) phosphorochloridate 22 as the coupling agent] at -40 deg C, followed by in situ sulfur transfer involving either 2-(4-chlorophenylsulfanyl)isoindole-1,3(2H)-dione 23a or 4-[(2-cyanoethyl)sulfanyl]morpholine-3,5-dione 26. The yields of the coupling and sulfur transfer reactions are virtually quantitative and, following unblocking by previously reported procedures, very pure products (d[ApC], d[TpGpApC], d[TpGp(s)ApC], d[Gp(s)A] and d[Cp(s)Tp(s)Gp(s)A]) are obtained.
Studies on aryl H-phosphonates. I. An efficient method for the preparation of deoxyribo- and ribonucleoside 3'-H-phosphonate monoesters by transesterification of diphenyl H-phosphonate
Jankowska,Sobkowski,Stawinski,Kraszewski
, p. 3355 - 3358 (2007/10/02)
A convenient method for the preparation of deoxyribonucleoside and ribonucleoside 3'-H-phosphonate monoesters via transesterification of diphenyl H-phosphonate with suitable protected nucleosides in pyridine is described.
