118353-05-2 Usage
Description
Carbovir is a nucleoside/nucleotide reverse transcriptase inhibitor (NRTI) that is an off-white solid. It is a synthetic compound designed to inhibit the activity of reverse transcriptase, an enzyme crucial for the replication of certain viruses, particularly retroviruses.
Uses
Used in Pharmaceutical Industry:
Carbovir is used as an antiviral agent for the treatment of retroviral infections, such as HIV and hepatitis B. It works by interfering with the viral replication process, thereby helping to control the progression of the disease.
Used in Cancer Research:
Carbovir is used as a research tool in the study of cancer, particularly in the context of human hepatoma carcinoma cells. It has been found to cause mitochondrial toxicity in these cells, which can provide valuable insights into the development of novel cancer therapies.
Used in Drug Development:
Due to its antiviral properties, Carbovir is also used in the development of new drugs and therapies for the treatment of various viral infections. Its mechanism of action as an NRTI makes it a valuable compound for further research and potential application in the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 118353-05-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,8,3,5 and 3 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 118353-05:
(8*1)+(7*1)+(6*8)+(5*3)+(4*5)+(3*3)+(2*0)+(1*5)=112
112 % 10 = 2
So 118353-05-2 is a valid CAS Registry Number.
InChI:InChI=1/C11H13N5O2/c12-11-14-9-8(10(18)15-11)13-5-16(9)7-2-1-6(3-7)4-17/h1-2,5-7,17H,3-4H2,(H3,12,14,15,18)
118353-05-2Relevant articles and documents
Synthesis of cyclopentenyl carbanucleosides via palladium(0) catalysed reactions
Kapeller,Marschner,Weissenbacher,Griengl
, p. 1439 - 1456 (2007/10/03)
Methyl 4-acetoxycyclopent-2-enylmethylcarboxylate (2) and the corresponding carbonate 3 have been treated with sodium salts and aluminum amides of pyrimidines, purines and methyl 1H-1,2,4-triazole-3-carboxylate with a catalyst formed from bis(dibenzylideneacetone)palladium(0) and triisopropyl phosphite to give the corresponding carbanucleosides in good to excellent yields. This method was also applied for a synthesis of carbovir (31).
New efficient method for the synthesis of the antiviral agent carbovir
Jung, Michael E.,Rhee, Hakjune
, p. 4449 - 4452 (2007/10/02)
An efficient synthesis of (±)-carbovir 1 and simple des(hydroxymethyl) analogues, e.g., 5, is reported which uses a new approach for attaching nucleoside bases to cycloalkene systems.
Pd(0)-catalyzed allylic alkylation in the synthesis of (±)carbovir
Gundersen, Lise-Lotte,Benneche, Tore,Undheim, Kjell
, p. 1085 - 1088 (2007/10/02)
Racemic carbovir 1 has been synthesized in 6 steps from the cyclopentanone 8 with a Pd(0)-catalyzed allylation as a key reaction.
