118460-50-7Relevant articles and documents
Ligand-controlled regiodivergent palladium-catalyzed decarboxylative allylation reaction to access α,α-difluoroketones
Yang, Ming-Hsiu,Orsi, Douglas L.,Altman, Ryan A.
, p. 2361 - 2365 (2015/03/04)
α,α-Difluoroketones possess unique physicochemical properties that are useful for developing therapeutics and probes for chemical biology. To access the α-allyl-α,α-difluoroketone substructure, complementary palladium-catalyzed decarboxylative allylation reactions were developed to provide linear and branched α-allyl-α,α-difluoroketones. For these orthogonal processes, the fluorination pattern of the substrate enabled the ligands to dictate the regioselectivity of the transformations.
Electrochemical fluorination of β-dicarbonyl compounds using p-iodotoluene difluoride as a mediator
Hara, Shoji,Hatakeyama, Tsuyoshi,Chen, Sheng-Qi,Ishi-I, Kenji,Yoshida, Masanori,Sawaguchi, Masanori,Fukuhara, Tsuyoshi,Yoneda, Norihiko
, p. 189 - 192 (2007/10/03)
The selective and direct introduction of the fluorine atom into the α-position of β-dicarbonyl compounds was electrochemically achieved using iodotoluene difluoride as the mediator. The resulting α-fluoro-β-dicarbonyl compounds are important building blocks for biologically active compounds.
