1185246-14-3

Basic information

• Product Name: (R)-AMlodipine-d4
• Synonyms: (R)-AMlodipine-d4;(+)-AMlodipine-d4;(4R)-2-[[2-AMino(ethoxy-d4)]ethyl]-4-(2-chlorophenyl)-1,4-dihydro-6-Methyl-3,5-pyridinedicarboxylic Acid 3-Ethyl 5-Methyl Ester;d-AMlodipine-d4;(R,S)-AMlodipine-d4;2-[(2-AMinoethoxy)Methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-Methoxycarbonyl)-6-Methyl-1,4-dihydropyridine-d4;AMlopres-d4;Intervask-d4
• CAS NO: 1185246-14-3
• Molecular Formula: C20H25ClN2O5
• Molecular Weight: 408.8759
• Product Categories: Amines;Chiral Reagents;Dihydropyridine;Heterocycles;Intermediates & Fine Chemicals;Isotope Labelled Compounds;Pharmaceuticals
• Mol File: 1185246-14-3.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Methanol (Sparingly)
• CAS DataBase Reference: (R)-AMlodipine-d4(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-AMlodipine-d4(1185246-14-3)
• EPA Substance Registry System: (R)-AMlodipine-d4(1185246-14-3)

Safety Data

• Hazardous Substances Data: 1185246-14-3(Hazardous Substances Data)

Usage

Description

(R)-AMlodipine-d4 is a labelled (R)-enantiomer of Amlodipine, a dihydropyridine calcium channel blocker. It is a white solid and is primarily used as a reference compound in analytical and research applications.

Uses

Used in Pharmaceutical Research:
(R)-AMlodipine-d4 is used as a reference compound for the development and validation of analytical methods, such as high-performance liquid chromatography (HPLC) and mass spectrometry, for the quantification and determination of Amlodipine in pharmaceutical formulations.
Used in Enantiomer Separation:
(R)-AMlodipine-d4 is used as a chiral reference standard for the separation and identification of enantiomers in chiral chromatography techniques, such as chiral HPLC and capillary electrophoresis.
Used in Drug Metabolism Studies:
(R)-AMlodipine-d4 is used as an internal standard in drug metabolism studies to monitor the pharmacokinetics and pharmacodynamics of Amlodipine and its metabolites in biological samples.
Used in Quality Control:
(R)-AMlodipine-d4 is used as a quality control standard to ensure the accuracy and reliability of Amlodipine measurements in pharmaceutical quality control laboratories.
Note: Although the provided materials mention that the activity of Amlodipine resides mainly in the (-)-isomer, (R)-AMlodipine-d4 is still valuable for the aforementioned applications.