118554-32-8Relevant articles and documents
Allenes. Part 47. Pyridopyrimidines and their Hydrolysis Products from Allenic and Acetylenic Nitriles
Landor, Stephen R.,Landor, Phyllis D.,Johnson, Andrew,Fomum, Z. Tanee,Mbafor, J. Tanyi,Nkengfack, A. Ephraim
, p. 975 - 980 (2007/10/02)
The reactions between 2-aminopyridine, C-substituted 2-aminopyridines, and allenic nitriles or phenylpropynenitrile give, initially, 2-amino-2H-pyridopyrimidines which are moderately stable under acidic conditions but undergo addition of water with extreme ease under basic conditions to form 4-hydroxypyridopyrimidines.These undergo ring cleavage when refluxed in ethanol to pyridyl ketones (5).