1185763-41-0

Basic information

• Product Name: (E)-4,5-dichloro-2-(4-iodostyryl)pyridazine-3(2H)-one
• CAS NO: 1185763-41-0
• Molecular Weight: 393.011
• Mol File: 1185763-41-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (E)-4,5-dichloro-2-(4-iodostyryl)pyridazine-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-4,5-dichloro-2-(4-iodostyryl)pyridazine-3(2H)-one(1185763-41-0)
• EPA Substance Registry System: (E)-4,5-dichloro-2-(4-iodostyryl)pyridazine-3(2H)-one(1185763-41-0)

Safety Data

• Hazardous Substances Data: 1185763-41-0(Hazardous Substances Data)

Upstream product

• 15164-44-0 p-(iodophenyl)carboxaldehyde 
• 51356-03-7 4,5-dichloro-2-chloromethyl-pyridazin-3(2H)-one 
• 1012342-68-5 ((4,5-dichloro-6-oxopyridazine-1(6H)-yl)methyl)triphenyl phosphonium iodide 

Relevant articles and documents

METHOD FOR DETECTING AMYLOID AGGREGATES USING STYRYLPYRIDAZINE-ONE DERIVATIVES

The present invention relates to a composition for detecting beta amyloid aggregates and a composition for diagnosing beta amyloid aggregation disease, comprising a 2-styrilpyridizine-3(2H)-one derivative or its pharmaceutically acceptable salt, to a diagnostic kit for diagnosing beta amyloid aggregation disease comprising said composition and to a method for detecting beta amyloid aggregates using said compositions to provide information for beta amyloid aggregation disease diagnosis.

Substituent-dependence of photophysical properties of trans-2- styrylpyridazin-3(2H)-ones

(Figure Presented) The photophysical behavior of trans-2-styrylpyridazin- 3(2H)-ones 3 strongly depend on the number and the position of substituents in the phenyl ring in THF, methylene chloride, acetonitrile and methanol. The absorption spectra of 3 containing the electron-donating substituents at the para-position show the red-shift, whereas the spectra of 3 containing the electron-withdrawing substituents show the blueshift. For the trans-2-(p-substituted-styryl)pyridazin-3(2H)-ones 3b-3h and 3k-3o, the magnitude of the solvatochromic shifts and the shape of the fluorescence spectra depend on the number and/or the position of substituents in benzene ring. The emission maximum of trans-2-styrylpyridazin-3(2H)-ones involving the electron-donating group is larger than one of trans-2-styrylpyridazin-3(2H)-ones involving the electron-withdrawing group in the phenyl ring. The magnitude of the emission maximum is roughly parallel to the relative electron-withdrawing ability of the substituents of the phenyl ring.