1185763-47-6Relevant articles and documents
METHOD FOR DETECTING AMYLOID AGGREGATES USING STYRYLPYRIDAZINE-ONE DERIVATIVES
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Paragraph 0093; 0094, (2014/05/20)
The present invention relates to a composition for detecting beta amyloid aggregates and a composition for diagnosing beta amyloid aggregation disease, comprising a 2-styrilpyridizine-3(2H)-one derivative or its pharmaceutically acceptable salt, to a diagnostic kit for diagnosing beta amyloid aggregation disease comprising said composition and to a method for detecting beta amyloid aggregates using said compositions to provide information for beta amyloid aggregation disease diagnosis.
Substituent-dependence of photophysical properties of trans-2- styrylpyridazin-3(2H)-ones
Bo, Ram Kim,Cho, Su-Dong,Lee, Hyung-Geun,Yim, Heung-Seop,Kim, Min-Jung,Hwang, Jaeyoung,Park, Song-Eun,Kim, Jeum-Jong,Jung, Kwang-Ju,Yoon, Yong-Jin
experimental part, p. 691 - 701 (2009/11/30)
(Figure Presented) The photophysical behavior of trans-2-styrylpyridazin- 3(2H)-ones 3 strongly depend on the number and the position of substituents in the phenyl ring in THF, methylene chloride, acetonitrile and methanol. The absorption spectra of 3 containing the electron-donating substituents at the para-position show the red-shift, whereas the spectra of 3 containing the electron-withdrawing substituents show the blueshift. For the trans-2-(p-substituted-styryl)pyridazin-3(2H)-ones 3b-3h and 3k-3o, the magnitude of the solvatochromic shifts and the shape of the fluorescence spectra depend on the number and/or the position of substituents in benzene ring. The emission maximum of trans-2-styrylpyridazin-3(2H)-ones involving the electron-donating group is larger than one of trans-2-styrylpyridazin-3(2H)-ones involving the electron-withdrawing group in the phenyl ring. The magnitude of the emission maximum is roughly parallel to the relative electron-withdrawing ability of the substituents of the phenyl ring.