1185763-53-4

Basic information

• Product Name: (E)-4,5-dichloro-2-(2-methoxystyryl)pyridazine-3(2H)-one
• CAS NO: 1185763-53-4
• Molecular Weight: 297.141
• Mol File: 1185763-53-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (E)-4,5-dichloro-2-(2-methoxystyryl)pyridazine-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-4,5-dichloro-2-(2-methoxystyryl)pyridazine-3(2H)-one(1185763-53-4)
• EPA Substance Registry System: (E)-4,5-dichloro-2-(2-methoxystyryl)pyridazine-3(2H)-one(1185763-53-4)

Safety Data

• Hazardous Substances Data: 1185763-53-4(Hazardous Substances Data)

Upstream product

• 135-02-4 ortho-anisaldehyde 
• 51356-03-7 4,5-dichloro-2-chloromethyl-pyridazin-3(2H)-one 

Relevant articles and documents

Fluorescent 2-styrylpyridazin-3(2H)-one derivatives as probes targeting amyloid-beta plaques in Alzheimer's disease

Amyloid plaques, which are primarily composed of aggregated amyloid-beta (Aβ) peptide, are the neuropathological hallmarks of Alzheimer's disease (AD). Fluorescent markers containing 2-styrylpyridazin-3(2H)-ones were developed to detect intracellular aggregated Aβ peptides. Nine compounds exhibited a greater than 10-fold increase of in emission spectra before and after mixing with Aβ aggregates compared with before mixing. Among these compounds, compound 9n exhibited the highest affinity for Aβ aggregates (Kd = 1.84 μM) and selectively stained both aggregated intracellular Aβ and Aβ plaques in the transgenic AD model mice (APP/PS1). These preliminary results indicate that 2-styrylpyridazin-3(2H)-one derivatives are promising alternative fluorescence imaging agent for the study of AD.