1186019-61-3Relevant articles and documents
Symmetrical approach of spiro-pyrazolidinediones as acetyl-CoA carboxylase inhibitors
Kamata, Makoto,Yamashita, Tohru,Kina, Asato,Tawada, Michiko,Endo, Satoshi,Mizukami, Atsushi,Sasaki, Masako,Tani, Akiyoshi,Nakano, Yoshihide,Watanabe, Yuuki,Furuyama, Naoki,Funami, Miyuki,Amano, Nobuyuki,Fukatsu, Kohji
, p. 4769 - 4772 (2012/08/07)
Spiro-pyrazolidinedione derivatives without quaternary chiral center were discovered by structure-based drug design and characterized as potent acetyl-CoA carboxylase (ACC) inhibitors. The high metabolic stability of the spiro-pyrazolo[1,2-a]pyridazine sc